H-2 Antigens pp 209-218 | Cite as

Mutation of the Splice Acceptor Sites at the 5’End of Exon 2 of H-2Kd and H-2Dd Results in the Expression of Altered Class I Antigens Expressed on the Membrane of L Cells

  • Mary Lynne Hedley
  • Philip Tucker
  • James Forman
Part of the NATO ASI Series book series (NSSA, volume 144)


Major histocompatibility complex (MHC) class I antiens are highly polymorphic proteins expressed on the surface of most murine cells. These glycoproteins have a molecular weight of 37–45,000 daltons and are noncovalently associated with the nonpolymorphic β2-microglobulin light chain. The classical transplantation antigens H-2K, -D, and -L serve as restriction elements for viral and tumor antigens and thereby allow the specific recognition of target cells by cytotoxic T lymphocytes (CTL).


Alternative Splice Splice Site P815 Cell Acceptor Site Acceptor Splice Site 


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Mary Lynne Hedley
    • 1
  • Philip Tucker
    • 1
  • James Forman
    • 1
  1. 1.University of Texas Health Science Center at DallasDallasUSA

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