Mutation of the Splice Acceptor Sites at the 5’End of Exon 2 of H-2Kd and H-2Dd Results in the Expression of Altered Class I Antigens Expressed on the Membrane of L Cells
Major histocompatibility complex (MHC) class I antiens are highly polymorphic proteins expressed on the surface of most murine cells. These glycoproteins have a molecular weight of 37–45,000 daltons and are noncovalently associated with the nonpolymorphic β2-microglobulin light chain. The classical transplantation antigens H-2K, -D, and -L serve as restriction elements for viral and tumor antigens and thereby allow the specific recognition of target cells by cytotoxic T lymphocytes (CTL).
KeywordsAlternative Splice Splice Site P815 Cell Acceptor Site Acceptor Splice Site
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