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H-2 Antigens pp 133-138 | Cite as

Some Recent Data on the Q-Subregion Genes and Their Products

  • Lorraine Flaherty
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

For the last ten years we have concentrated our studies on the Q genes of the murine major histocompatibility complex (MHC). These genes determine a series of class I molecules which are 80–90% homologous to the more classical H-2K and H-2D genes. Because of this homology, we have frequently hypothesized that these genes have an important function in the immune system. However, recent data showing large deletions in the Q subregion, without any overt effects on survival, have cast some doubt on this hypothesis.

Keywords

Major Histocompatibility Complex Congenic Strain Inositol Trisphosphate Variant Surface Glycoprotein Preimplantation Mouse Embryo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Lorraine Flaherty
    • 1
  1. 1.Wadsworth Center for Laboratories and ResearchNew York State Department of HealthAlbanyUSA

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