Guanidines pp 49-58 | Cite as

Developmental Changes in Guanidino Compounds Levels in Mouse Organs

  • Yoko Watanabe
  • Shoichiro Shindo
  • Akitane Mori

Abstract

Many kinds of guanidino compounds are known to be existent in mammalian organsl, and they are thought to be related to nitrogen metabolism. There have been many reports of guanidino compound levels in human body fluids and animal organs changing under various pathological conditions. Methylguanidine (MG) and guanidinosuccinic acid (GSA) in serum are elevated in uremic patients2,3. Increased excretion of α-keto-δ-guanidinovaleric acid in urine was observed in patients with hyperargininaemia4. High concentrations of taurocyamine in the cerebrospinal fluid of some epileptic patients have been observed5. Yokoi et al.6,7 showed the homoarginine (HArg) level to be high in liver, kidney and serum of rats administered alcohol chronically. These observations suggest that guanidino compound levels in organs may change according to physiological conditions. It is possible that the levels of guanidino compounds may also change during maturation when physiological conditions are thought to be undergoing change. The data reported herein are the results of a study of developmental changes in the levels of guanidino compounds in mouse organs.

Keywords

Urea Lysine Arginine Stein Creatine 

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Yoko Watanabe
    • 1
  • Shoichiro Shindo
    • 1
  • Akitane Mori
    • 1
  1. 1.Department of Neurochemistry, Institute for NeurobiologyOkayama University Medical SchoolOkayama 700Japan

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