Guanidinoacetic Acid (GAA) Deficiency and Supplementation in Rats with Chronic Renal Failure (CRF)
Guanidinoacetic acid (GAA) is the precursor of creatine which is essential in the energy metabolism of muscle and nerve tissue1. GAA is demonstrated to be produced mainly by the kidney2. Therefore, a decrease in GAA-producing tissue due to diseased kidney, could lead to a deficiency in creatine, the major matabolite of GAA.
KeywordsChronic Renal FAlLURE Total Creatine Guanidinoacetic Acid Total Creatine Content Experimental Chronic Renal FAlLURE
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