Metabolic Profiles of Guanidino Compounds in Various Tissues of Uremic Rats
Several guanidino compounds are implicated as toxic metabolites responsible for the systemic effects of uremia. Serum concentrations of methylguanidine and guanidinosuccinic acid were reported increased in patients with end-stage renal failure1,2. Serum profiles of guanidino compounds in uremia, however, might not reflect metabolic alterations of these compounds in tissues. Therefore, we investigated the levels of guanidino compounds in various tissue preparations obtained from rats made experimentally uremic by sub-total nephrectomy or bilateral ligation of the ureters.
KeywordsAcute Renal Failure Chronic Renal Failure Guanidino Compound Guanidinoacetic Acid Bilateral Ligation
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