Advertisement

Guanidines pp 343-351 | Cite as

The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure

  • Mitsuhiro Miyazaki
  • Kazumasa Aoyagi
  • Shoji Ohba
  • Sohji Nagase
  • Mitsuharu Narita
  • Shizuo Tojo

Abstract

Serum concentrations of urea and creatinine increase in patients with decreased renal function. Urea has been demonstrated to undergo enterohepatic circulation1,2,3,4. Creatinine has also been thought to have an enterohepatic circulation in patients with decreased renal function5,6,7. Serum concentrations of some guanidino compounds, especailly guanidinosuccinic acid (GSA) and methylguanidine (MG) increase in uremic states8,9,10,11. We reported that urea stimulated the synthesis of GSA in isolated rat hepatocytes12,13,14. Cohen proposed that MG might be produced from creatinine15.

Keywords

Chronic Renal Insufficiency Serum Creatinine Concentration Enterohepatic Circulation Uremic Toxin Malignant Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. Walser and L. J. Bodenlos, Urea metabolism in man, J. Clin. Invest., 38: 1617 (1956).CrossRefGoogle Scholar
  2. 2.
    M. Walser, Urea metabolism in chronic renal failure, J. Clin. Invest., 53: 1385 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    J. J. Brown, M. J. Hill and P. Richards, Bacterial ureases in uraemic man, Lancet, 11: 406 (1971).CrossRefGoogle Scholar
  4. 4.
    E. A. Jones, R. A. Smallwood, A. Craigie and V. M. Rosenoer, The enterohepatic circulation of urea nitrogen, Clin. Sci., 37: 825 (1969).PubMedGoogle Scholar
  5. 5.
    S. Giovannetti, P. 1. Balestri and G. Barsotti, Methyl-guanidine in uremia, Arch. Intern. Med., 131: 709 (1973).CrossRefGoogle Scholar
  6. 6.
    J. D. Jones and P. C. Burnett, Creatinine metabolism in humans with decreased renal function - creatinine deficit, Clin. Chem., 20: 1204 (1974).PubMedGoogle Scholar
  7. 7.
    J. D. Jones and P. C. Burnett, Creatinine metabolism and toxicity, Kidney International., 7: 294 (1975).Google Scholar
  8. 8.
    J. E. Bonas, B. D. Cohen and S. Natelson, Separation and estimation of certain guanidino compounds - application to the human urine, Microchem. J., 7: 63 (1963).CrossRefGoogle Scholar
  9. 9.
    S. Natelson, I. Stein and J. E. Bonas, Improvement in the method of separation of guanidino organic acids by column chromatography - isolation and identification of guanidinosuccinic acid from human urine, Microchem. J., 8: 371 (1964).CrossRefGoogle Scholar
  10. 10.
    B. D. Cohen, Guanidinosuccinic acid in uremia, Arch. Intern. Med., 126: 846 (1970).CrossRefGoogle Scholar
  11. 11.
    Y. Tofuku, M. Kuroda, T. KIta, and R. Takeda, Studies on guanidino compounds in uremia - reevaluation of serum GSA in relation to acute symptoms of uremia, Jpn. J. Nephrol., 22: 249 (1980).Google Scholar
  12. 12.
    S. Ohba, K. Aoyagi and S. Tojo, On the biosynthesis of guanidinosuccinic acid in rat liver - effect of urea, ornithine and D,L-norvaline, Jpn. J. Nephrol., 24: 1147 (1982).Google Scholar
  13. 13.
    K. Aoyagi, S. Ohba, M. Narita and S. Tojo, Biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes -II inhibition of its synthesis by urea cycle members and D,L-norvaline, Jpn. J. Nephrol., 24: 1137 (1982).Google Scholar
  14. 14.
    K. Aoyagi, S. Ohba, M. Miyazaki, S. Iida, K. Watanabe,M. Narita and S. Tojo, Biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes - 1 stimulation of its synthesis by urea, Jpn. J. Nephrol., 24: 345 (1982).Google Scholar
  15. 15.
    B. D. Cohen, Uremic toxins, Bull. N. Y. Acad. Med., 51: 1228 (1975).PubMedGoogle Scholar
  16. 16.
    Y. Yamamoto, T. Manji, A. Saito, K. Maeda and K. Ohta, Ion-exchange chromatographic separation and fluorometric determination of guanidino compounds in physiological fluids, J. Chromatogra., 162: 327 (1979).CrossRefGoogle Scholar
  17. 17.
    S. Nagase, K. Aoyagi and S. Tojo, On methylguanidine synthesizing organs - estimation from short term effect of creatinine, Jpn. J. Nephrol., (in press)Google Scholar
  18. 18.
    T. Aoyagi and W. H. J. Summerskill, Inhibition by acetohydroxamic acid of human mucosal and faecal urease-specific activity, Lancet, 1: 296 (1966).PubMedCrossRefGoogle Scholar
  19. 19.
    J. Bircher, U. P. Haemmerli and G. Scollo-Lavizzari, Treatment of chronic portal - systemic encephalopathy with lactulose, Am. J. Med., 51: 148 (1971).PubMedCrossRefGoogle Scholar
  20. 20.
    D. O. Castell and E. W. Moore, Ammonia absorption from the human colon, the role of nonionic diffusion, Gastroent., 60: 33 (1971).Google Scholar
  21. 21.
    F. Simmons, H. Goldstein and J. D. Boyle, A controlled cinical trial of lactulose in hepatic encephalopathy, Gastroent., 59: 827 (1970).Google Scholar
  22. 22.
    G. Rorsman and I. Sulg, Lactulose treatment of chronic hepatopotal encephalopathy, a clinical and electroencephalographic study, Acta Med. Scand., 187: 337 (1970).PubMedCrossRefGoogle Scholar
  23. 23.
    N. K. Man, T. Drueke, J. Paris, C. Elizalde-Monteverde, M. Rondon-Nucete, J. Zingraff and P. Jungers, Increased nitrogen removal from the intestinal tract of uraemic patients, Proc. Euro. Dialysis Transplant Ass., 10: 143 (1973).Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Mitsuhiro Miyazaki
    • 1
  • Kazumasa Aoyagi
    • 1
  • Shoji Ohba
    • 1
  • Sohji Nagase
    • 1
  • Mitsuharu Narita
    • 1
  • Shizuo Tojo
    • 1
  1. 1.Department of Internal Medicine, Institute of Clinical MedicineThe University of TsukubaSakura-mura, Ibaraki-ken, 305Japan

Personalised recommendations