The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure
Serum concentrations of urea and creatinine increase in patients with decreased renal function. Urea has been demonstrated to undergo enterohepatic circulation1,2,3,4. Creatinine has also been thought to have an enterohepatic circulation in patients with decreased renal function5,6,7. Serum concentrations of some guanidino compounds, especailly guanidinosuccinic acid (GSA) and methylguanidine (MG) increase in uremic states8,9,10,11. We reported that urea stimulated the synthesis of GSA in isolated rat hepatocytes12,13,14. Cohen proposed that MG might be produced from creatinine15.
KeywordsChronic Renal Insufficiency Serum Creatinine Concentration Enterohepatic Circulation Uremic Toxin Malignant Hypertension
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