Advertisement

Guanidines pp 327-334 | Cite as

Urinary Guanidinoacetic Acid Excretion in Gentamicin Nephrotoxicity

  • Hideo Itabashi
  • Hisaki Rinno
  • Hikaru Koide

Abstract

Bonas et al. reported in 1963 that four patients with kidney disease were shown to excrete markedly decreased amounts of guanidinoacetic acid (GAA) in their urine1.

Keywords

Serum Urea Nitrogen Urinary Enzyme Urinary Activity Urinary Creatinine Excretion Guanidino Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. E. Bonas, B. D. Cohen and s. Natelson, Separation and estimation of certain guanidino compound. Application to human urine, Microchem. J., 7:63–77 (1963).Google Scholar
  2. 2.
    M. Jaffe, Ueber den Niedershlag, welchen Pikrinsäure in normalem Harn erzeugt und über eine neue Reaction des kreatinins, Hoppe-Seyler Z, physiol. chem. 10: 391 (1886).Google Scholar
  3. 3.
    S. Imabayashi et al., Determination of individual ubiqinone homologues by mass spectrometry and high performance liquid chromatography, Analytical chemistry. 51, 534–536 (1979).Google Scholar
  4. 4.
    J. B. Walker, Formanidine group transfer in extracts of human pancreas, liver and kidney, Biochim. Biophys. Acta., 73:241–247 (1963).Google Scholar
  5. 5.
    M. Funahashi et al., Formation of arginine and guanidinoacetic acid in the kidney, J. Biochem. 89:1347–1356 (1981).Google Scholar
  6. 6.
    K. Kano et al., Clinical significance of guanidino compounds in uremia, J. Clin. Path. 28:660–664 (1980).Google Scholar
  7. 7.
    A. W. Mondorf, M. Zegelman et al., Comparative studies on the action of aminoglycosides and cephalosporins on the proximal tubule of the human kidney, Proceedings of the 10th International Congress of Chemotherapy Zurich, 1977,Abstract 270.Google Scholar
  8. 8.
    R. A. Proctor and C. M. Kunin, Salicylate-induced enzymuria, Am. J. Med. 65:987–993 (1978).Google Scholar
  9. 9.
    P. R. Beck, R. B. Thompson and A. K. R. Chadhuri, Aminoglycoside antibiotics and renal function: Changes in urinary -glutamyltransferase excretion, J. Clin. Pathol 30:432–437 (1977).Google Scholar
  10. 10.
    J. M. Wellwood, D. Lovell, A. E. Thompson et al., Renal damage caused by gentamicin: A study of the effects on renal morphology and urinary enzyme excretion, J. Pathol. 118:171–182 (1976).Google Scholar
  11. 11.
    W. E. Stroo and B. J. Hook, Enzymes of renal origin in urine as indicators of nephrotoxicity, Toxicol. Appl. Pharmacol.,39:423–434 (1977).Google Scholar
  12. 12.
    F. G. Falco, H. M. Smith and G. M. Aricieri, Nephrotoxicity of aminoglycosides and gentamicin, J. Infect. Dis. 119:406–409 (1969).Google Scholar
  13. 13.
    G. G. Jack, Current therapeutics. CCXXXIV. Gentamicin, Practitioner 198: 855–866 (1967).Google Scholar
  14. 14.
    M. Abramowitz and C. M. Edelmann Jr., Nephrotoxicity of antiinfective drugs, Clin. Pediat. 7:389–390 (1968).Google Scholar
  15. 15.
    J. N. Wilfert et al., Renal insufficiency associated with gentamicin therapy, J. Infect. Dis. 124 (Suppl) S148–S115 (1971).Google Scholar
  16. 16.
    N. Milman, Renal failure associated with gentamicin therapy, Acta. Med. Scand. 196:87–91 (1974).Google Scholar
  17. 17.
    J. C. Kosek, R. I. Mazze and M. J. Cousins, Nephrotoxicity of gentamicin, Lab. Invest. 30:48–57 (1974).Google Scholar
  18. 18.
    Y. Tatsukawa, Y. Dohi et al., The role of coenzyme Qlofor preservation of the rats kidney: A model experiment for kidney transplantation, Life Science 24: 1309 (1979).Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Hideo Itabashi
    • 1
  • Hisaki Rinno
    • 1
  • Hikaru Koide
    • 1
  1. 1.Division of Nephrology, Department of MedicineJuntendo University School of MedicineTokyo 133Japan

Personalised recommendations