Guanidinoacetic Acid (GAA) in Patients with Chronic Renal Failure (CRF) and Diabetes Mellitus (DM)
Guanidinoacetic acid (GAA) is the precursor of creatine, an essential element in the energy metabolism of musle and nerve tissue1. GAA itself may have some physiological role such as the stimulation of insulin secretion2. As shown in Fig. 1, GAA is mainly produced in the kidney by the transamidination of glycine from arginine.
KeywordsChronic Renal Failure Diabetes Mellitus Patient Chronic Glomerulonephritis High Performance Liquid Chro Guanidine Derivative
Unable to display preview. Download preview PDF.
- 2.R. N. Alserver, R. H. Georg and K. E. Sussman, Stimulation of insulin secretion by guanidinoacetic acid and other guanidine derivatives, Endocrinology 86: 332 (1970).Google Scholar
- 3.M. Funahashi, H. Kato, S. Shiosaka and H. Nakagawa, Formation of arginine and guanidinoacetic acid in the kidney in vitro, J. Biochem. 89:1347 (1981).Google Scholar
- 6.C. H. Gold, V. Margaratha and D. V. A. Mzamane, The lack of effect of guanidino acetic acid on in vitro osmotic frag ility of erythrocytes, Nephron 31: 17 (1982).Google Scholar
- 7.Y. Yamamoto, T. Manji, A. Saito, K. Maeda and K. Ohta, Ion-exchange chromatographic separation and fluorometric determination of guanidino compounds in physiological fluids, J. Chromato. 162:327 (1979).Google Scholar
- 8.M. Matsumoto, H. Kishikawa and A. Mori, Guanidino compounds in the sera of uremic patients and in the sera and brain of experimental uremic rabbits, Biochem. Med. 16:1 (1976).Google Scholar
- 10.Y. Tsubakihara, N. Lida, Y. Orita, A. Ando, K. Nakata, H. Mikami, S. Miki, N. Maruta and H. Abe, Determination of uremic toxins, Jap. J. Clin. Chem. 7:208 (1979).Google Scholar
- 11.A. Ando, T. Kikuchi, H. Mikami, Y. Orita and H. Abe, An automated analytical method for guanidino compounds, Jap. J. Clin. Chem. 9:19 (1980).Google Scholar
- 12.T. Hoshino, Recommended deproteinizing methods for plasma guanidino compound analysis by liquid chromatography, in: “Urea Cycle Disease,” A. Lowenthal, A. Mori and B. Marescau, eds., Plenum Press, New York, 391 (1982).Google Scholar
- 13.J. D. Jones and P. C. Burnett, Creatinine metabolism in humans with decreased renal function; creatinine deficit, Clin. Chem. 20:1204 (1974).Google Scholar
- 14.J. B. Walker, Role for pancreas in biosynthesis of creatine, Proc. Soc. Exp. Biol. and Med. 98:7 (1958).Google Scholar
- 15.W. H. Horner, Transamidination in nephrectomized rat, J. Biol. Chem. 234:2386 (1956).Google Scholar