Guanidines pp 33-38 | Cite as

Simple Methods for the Determination of Methylguanidine and Guanidinosuccinic Acid in Biological Fluids

  • Toshiyuki Nakao
  • Seiji Fujiwara
  • Tadashi Miyahara


It is recognized that guanidino derivatives significantly accumulate in uremic patients and contribute to the toxic manifestations of uremia. Among those compounds, both methylguanidine (MG) and guanidinosuccinic acid (GSA) have been especially interesting for their role as uremic toxinsl. As the implications of MG and GSA as uremic toxins has become more obvious, routine measurement of those substances in biological fluids has assumed increasing importance in managing uremic patients to observe the effects of treatment.


Succinic Acid Biological Fluid Uremic Patient Uremic Toxin High Performance Liquid Chroma 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Toshiyuki Nakao
    • 2
  • Seiji Fujiwara
    • 1
  • Tadashi Miyahara
    • 1
  1. 1.Second Department of Internal MedicineJikei University School of Medicine TokyoJapan
  2. 2.Saiseikai Central HospitalTokyoJapan

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