Abstract
It is well known that various nitrogenous metabolites accumulate in the blood of uremic patients1,2. These substances, which occur in uremic blood in elevated concentrations, are considered to be toxic and to give rise to many uremic symptoms.
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References
J. Bergstrom and E. E. Bittar, The basis of uremic toxicity, in:“The biological basis of medicine,” E. E. Bittar and N. Bittar, eds., Academic press, New York (1969).
J. D. Kopple, Nitrogen metabolism, in:“Textbook of nephrology,” S. G. Massry and R. J. Glassock, eds., Williams & Wilkins, Baltimore/London (1983).
G. Perez and R. Faluotico, Creatinine: A precursor of methyl-guanidine, Experientia 29: 1473 (1973).
J. J. Pfiffner and C. V. Myers, On colorimetric estimation of guanidine base in blood, J. Biol. Chem. 87: 345 (1930).
M. Gonella, G. Barsotti, S. Lupetti, S. Giovannetti, V. Campa and G. Falcone, Role of the aerobic gut flora on the creatinine and methylguanidine metabolism, in:“Proc. 6th Int. Congr. Nephrol. Florence,” S. Karger, Basel (1976).
D. J. Jones and P. C. Burnett, Creatinine metabolism and toxicity, Kidney Int. 7 (Suppl. 3): 295 (1975).
M. L. Simenhoff, Metabolism and toxicity of aliphatic amines, Kidney Int. 7 (Suppl. 3): 314 (1975).
M. L. Simenhoff, J. J. Saukkonen, J. F. Burke, R. W. Schaedler, W. H. Vogel, K. Boyce and N. Lasker, Importance of aliphatic amines in uremia, Kidney Int. 13 (Suppl. 8): 16 (1978).
Y. Yamamoto, A. Saito, T. Manji, H. Nishi, K. Ito, K. Maeda, K. Ohta and K. Kobayashi, A new automated analytical method for guanidino compounds and their cerebrospinal fluid levels in uremia, Trans. Am. Soc. Artif. Intern. Organs 24: 61 (1978).
A. Ando, T. Kikuchi, H. Mikami, M. Fujii, K. Yoshihara, Y. Orita and H. Abe, Quantitative determination of guanidino compounds: The excellent preparation of biological samples, in:“Urea cycle diseases,” A. Lowenthal, A. Mori and B. Marescau, eds., Plenum Publishing Co., New York (1983).
S. Baba, Y. Watanabe, F. Gejo and M. Arakawa, High-performance liquid chromatographic determination of serum aliphatic amines in chronic renal failure, Clin. Chim. Acta 136: 49 (1984).
F. Gejyo, Studies on the guanidine derivatives in chronic renal failure. A study on the specific method for measurement of guanidine derivatives, especially methylguanidine, and its clinical application, Jap. J. Nephrol. 16: 379 (1974).
S. R. Dunn, M. L. Simenhoff and L. G. Wesson, Gas chromatographic determination of free mono-, di-, and trimethylamine in biological fluids, Anal. Chem. 48: 41 (1976).
M. L. Simenhoff, H. E. Ginn and P. E. Teschan, Toxicity of aliphatic amines in uremia, Trans. Am. Soc. Artif. Intern. Organs 23: 560 (1977).
B. D. Cohen, Uremic toxins, Bull. N. Y. Acad. Med. 51: 1228 (1975).
H. Mikami, Y. Orita, A. Ando, M. Fujii, T. Kikuchi, K. Yoshihara, A. Okada and H. Abe, Metabolic pathway of guanidino compounds in chronic renal failure, in:“Urea cycle diseases,” A. Lowenthal, A. Mori and B. Marescau, eds., Plenum Publishing Co., New York (1983).
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Gejyo, F., Baba, S., Watanabe, Y., Kishore, B.K., Suzuki, Y., Arakawa, M. (1985). Possibility of a Common Metabolic Pathway for the Production of Methylguanidine and Dimethylamine in Chronic Renal Failure. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_29
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DOI: https://doi.org/10.1007/978-1-4757-0752-6_29
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