Guanidino Compounds in Patients with Acute Renal Failure
Alterations in urea cycle activity in acute renal failure (ARF) may have important metabolic consequences. There are many reports which study the concentration of guanidino compounds (GC) in the sera of patients with chronic renal failure (CRF) and the relationship of these substances to the degree of renal failure1. In a recent publication2, we pointed out that there were very few reports on GC in ARF and that the relative importance of the plasma level of GC in the pathogenesis of ARF was uncertain. To predict the clinical course of ARF, it might be useful clinically to know of changes in GC, many of which are potential uremic toxins. As reported at the fifth Symposium on the Analysis of GC in Japan (Osaka, 1982), it is of interest to trace variations in GC for determining the course and prognosis of ARF. The purpose of this study is to trace the clinical meaning of GC in ARF, and to observe changes in GC by making circle diagrams called guanidinograms. We describe our cumulative studies on GC in 50 patients with ARF.
KeywordsAcute Renal Failure Chronic Renal Failure Guanidino Compound Group Group Group Guanidinoacetic Acid
Unable to display preview. Download preview PDF.
- 1.S. Giovannetti, P. L. Balestri and G. Barcotti, Methylguanidine in uremia, Arch. Intern. Med. 131:709 (1973).Google Scholar
- 2.Y. Ochiai, S. Abe, T. Yamada, K. Tada and F. Kosaka, Guanidino compounds and hemodialysis, in:“Urea Cycle diseases,” A. Lowenthal, A. Mori and B. Marescau, eds., Plenum press, New York and London (1982).Google Scholar
- 3.J. Sawynok and J. K. Dawborn, Plasma concentration and urinary excretion of guanidine derivates in normal subjects and patients with renal failure, Clin. Exp. Pharmacol. Physiol. 2:1 (1975).Google Scholar
- 4.M. H. Carr and P. R. Schloerb, Analysis for guanidine and methylguanidine in uremic plasma, Anal. Biochem. 1:221 (1960).Google Scholar
- 5.B. D. Cohen, Guanidinosuccinic acid in uremia, Arch. Intern. Med. 126:846 (1970).Google Scholar
- 6.H. I. Horowitz, I. M. Stein, B. D. Cohen and J. G. White, Further studies on the platelet-inhibitory effect of GSA and its role in uremic bleeding, Am. J. Med. 49:336 (1970).Google Scholar
- 7.E. T. Lonergan, M. Semar and R. Lange, A dialysable toxic factor in uremia, Trans. Am. Soc. Artif. Intern. Organs 16: 269 (1970).Google Scholar
- 8.G. Perez, A. Rey, M. J. Micklus and I. Stein, Cation-exchange chromatography of guanidine derivatives in plasma of patients with chronic renal failure, Clin. Chem. 22:240 (1976).Google Scholar
- 9.M. Sasaki, K. Takahara and S. Natelson, Urinary guanidinoacetate/ guanidinosuccinate ratio: An indicator of Kidney dysfunction, Clin. Chem. 19:315 (1973)Google Scholar