Guanidines pp 249-261 | Cite as

Effect of Chronic Alcohol Administration on the Concentrations of Guanidino Compounds in Rat Organs

  • Isao Yokoi
  • Junji Toma
  • Akitane Mori


It is well known that chronic ethanol (EtOH) administration causes convulsions during the withdrawal period. It is also known that some guanidino compounds influence brain function; for example, methylguanidine1, α-guanidinoglutaric acid2 and taurocyamine3 induce epileptic EEG discharges and/or convulsions after intracerebral administration, and the α-guanidinoglutaric acid concentration increases in the cobalt-induced epileptic focus of the cat cerebral cortex4. There has been no report about the effects of chronic EtOH administration on the metabolism of guanidino compounds, nor on the effects of metabolic changes of guanidino compounds on the observed convulsions during the withdrawal period from EtOH.


Priming Dose Bipolar Recording Guanidino Compound Left Frontal Guanidinoacetic Acid 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Isao Yokoi
    • 1
  • Junji Toma
    • 1
  • Akitane Mori
    • 1
  1. 1.Department of Neurochemistry, Institute for NeurobiologyOkayama University Medical SchoolOkayama City 700Japan

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