Effect of Chronic Alcohol Administration on the Concentrations of Guanidino Compounds in Rat Organs
It is well known that chronic ethanol (EtOH) administration causes convulsions during the withdrawal period. It is also known that some guanidino compounds influence brain function; for example, methylguanidine1, α-guanidinoglutaric acid2 and taurocyamine3 induce epileptic EEG discharges and/or convulsions after intracerebral administration, and the α-guanidinoglutaric acid concentration increases in the cobalt-induced epileptic focus of the cat cerebral cortex4. There has been no report about the effects of chronic EtOH administration on the metabolism of guanidino compounds, nor on the effects of metabolic changes of guanidino compounds on the observed convulsions during the withdrawal period from EtOH.
KeywordsPriming Dose Bipolar Recording Guanidino Compound Left Frontal Guanidinoacetic Acid
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