Abstract
It has been reported that taurocyamine (guanidinoethanesulfonate)1, guanidinoacetic acid2, γ-guanidinobutyric acid3, N-acetylarginine4, methylguanidine5 and α-guanidinoglutaric acid6, are present in the mammalian brain and that these guanidino compounds induce violent convulsions after intracisternal injection into rabbits, dogs, cats and rats. N-amidinobenzamide7 and dibenzoylguanidine8, which do not occur naturally, have also been found to induce convulsions after intraperitoneal or intravenous injection into animals. Dibenzoylguanidine is thought to be a very suitable convulsant for the study of the convulsive mechanism, because it can easily pass the blood-brain-barrier and the latent time to induce convulsions is very long.
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Hiramatsu, M., Kabuto, H., Mori, A. (1985). Effect of Taurine, Taurocyamine and Anticonvulsants on Dibenzoylguanidine-Induced Convulsions and their Relation to Brain Monoamine Levels in ddY and El Mice. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_24
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DOI: https://doi.org/10.1007/978-1-4757-0752-6_24
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