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Effect of Methylguanidine on Muscle Protein Synthesis

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Book cover Guanidines

Abstract

Methylguanidine (MG) is increased in the serum of uremic patients1. Giovannetti et al. considered it one of the most important uremic toxins, since the administration of MG to dogs resulted in weight loss, gastrointestinal disturbance, anemia and so on2.

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Reference

  1. Y. Orita, A. Ando, Y. Tsubakihara, H. Mikami, T. Kikuchi, K. Nakata and H. Abe, Tissue and blood cell concentration of methylguanidine in rats and patients with chronic renal failure, Nephron., 27: 35 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. S. Giovannetti and G. Barsotti, Methylguanidine in uremia, Arch Intern Med., 131: 709 (1973).

    Article  PubMed  CAS  Google Scholar 

  3. J. U. Koppel, Nutritional management of chronic renal failure, Postgrad. Med., 4: 135 (1978).

    Google Scholar 

  4. T. Kikuchi, Y. Orita, A. Ando, H. Mikami, M. Fujii, A. Okada and H. Abe, Liquid-chromatographic determination of guanidino compounds in plasma and erythrocyte of normal persons and uremic patients, Clin. Chem., 27: 1899 (1981).

    PubMed  CAS  Google Scholar 

  5. G. Schmidt and J. Thannhauser, A method for the determination of deoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues, J. Biol. Chem., 161: 83 (1945).

    PubMed  CAS  Google Scholar 

  6. W. C. Schneider, Phosphorus compounds in animal tissues, J. Biol. Chem., 164: 747 (1946).

    PubMed  CAS  Google Scholar 

  7. W. C. Schneider, Determination of nucleic acids in tissues by pentose analysis, in:“Method in enzymology, vol 3,” Academic Press, New York, pp. 680 (1957).

    Chapter  Google Scholar 

  8. K. W. Giles and A. Myers, An improved diphenylamine method for the estimation of deoxyribonuleic acid, Nature, 4979: 93 (1965).

    Article  Google Scholar 

  9. H. Lowry, N. J. Rosebrough, A. L. Farr and R. L. Randall, Protein measurement with Folin phenol reagent,J. Biol. Chem., 193: 265 (1951).

    PubMed  CAS  Google Scholar 

  10. A. Yoshikawa and T. Masaki, Increase in protein synthetic activity in chicken muscular dystrophy, J. Biochem., 90: 1775 (1981).

    Google Scholar 

  11. J. E. Shackelford and H. G. Lebherz, Cell-free synthesis of fructose diphosphate aldolases A, B, and C, J. Biol. Chem., 254: 4220 (1979).

    PubMed  CAS  Google Scholar 

  12. J. C. Waterlow, P. J. Garlick and D. J. Willward, Protein synthesis and its regulation, in:“Protein turnover in mammalian tissues and in the whole body,” North-Holland, Amsterdam, pp.24 (1978).

    Google Scholar 

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© 1985 Springer Science+Business Media New York

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Fujii, M. et al. (1985). Effect of Methylguanidine on Muscle Protein Synthesis. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_20

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  • DOI: https://doi.org/10.1007/978-1-4757-0752-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0754-0

  • Online ISBN: 978-1-4757-0752-6

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