Pharmacokinetic Modeling of Gentamicin Release from a Prosthetic Heart Valve

  • L. S. Olanoff
  • J. M. Anderson
  • R. D. Jones


Sustained release of biological agents is a concept that has received increased attention over the past decade. The primary goal of sustained drug release is the prolonged delivery of a drug to a particular body compartment or anatomical target site. This goal is accomplished by the application of a therapeutic drug delivery system designed to control both temporal and spatial aspects of drug disposition.


Drug Release Pharmacokinetic Model Silicone Rubber Prosthetic Valve Prosthetic Heart Valve 


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • L. S. Olanoff
    • 1
    • 2
  • J. M. Anderson
    • 1
    • 2
  • R. D. Jones
    • 1
    • 2
  1. 1.Departments of Pathology and Macromolecular ScienceCase Western Reserve UniversityClevelandUSA
  2. 2.Division of Surgical ResearchSt. Luke’s HospitalClevelandUSA

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