Advertisement

Implantable Systems for Delivery of Insect Growth Regulators to Livestock.II

  • H. Jaffe
  • P. A. Giang
  • D. K. Hayes
  • J. A. Miller
  • B. H. Stroud

Abstract

During the past several years, our laboratories have been investigating the application of controlled-release technology to the control of arthropod pests of livestock.1 As a result we have developed methods whereby an active ingredient can be delivered at a controlled rate into the circulatory system of a host animal via implanted pellets or microcapsules to affect feeding parasitic insects or ticks. Our initial experiments involved the preparation and bioevaluation of injectable microcapsules of the systemic pesticide famphur (O-[p-(dimethylsulfamoyl)phenyl]O, O-dimethyl phosphorothioate) in biodegradable polymers.2 Subcutaneous injections of a suspension of these microcapsules into guinea pigs killed feeding ticks over an extended period by continuously releasing active ingredient into the host’s circulatory system. However, large injections were required because of the relatively low activity of famphur and the volume of sesame oil used to suspend the microcapsules. Thus, this treatment was impractical for cattle. We therefore sought to avoid these problems by developing controlled-release implants of systemic insect growth regulators (IGR’s).

Keywords

Insect Growth Regulator Research Triangle Institute Arthropod Pest Initial Burst Effect Organic Chemical Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Part I: H. Jaffe, J.A. Miller, P.A. Giang, D.K. Hayes, R.W. Miller, and C.M. Livingston, in: “Proceedings Symposium on Controlled Release of Bioactive Mat.,” R.W. Baker, ed., New Orleans (1979). 1. 39.Google Scholar
  2. 2.
    H. Jaffe, D.K. Hayes, P. Giang, R.O. Drummond, and T.M. Whetstone, in: “Proceedings Controlled Release Pesticide Symposium,” R. Goulding, ed., Corvallis 272 (1977).Google Scholar
  3. 3.
    R.E. Pfadt and T.R. Robb, Control Livestock Pests, Bull, 327R, Agricultural Experiment Station, Univ. of Wyoming, Laramie 16–20 (1966).Google Scholar
  4. 4.
    J.A. Miller, M.L. Beadles, and W.L. Gladney, in: “Proceedings Controlled Release Pesticide Symposium,” R. Goulding, ed., Corvallis 253 (1977).Google Scholar
  5. 5.
    R.L. Harris, E.D. Frazar, and R.L. Younger, J. Econ. Entomol. 66: 1099 (1973).PubMedGoogle Scholar
  6. 6.
    R.L. Harris, W.F. Chamberlain, and E.D. Frazar, J. Econ. Entomol 67: 384 (1974).PubMedGoogle Scholar
  7. 7.
    M.L. Beadles, J.A. Miller, W.F. Chamberlain, J.L. Eschles, and R.L. Harris, J. Econ. Entomol. 68: 781 (1975).PubMedGoogle Scholar
  8. 8.
    J.A. Miller, W.F. Chamberlain, M.L. Beadles, M.O. Pickens, and A.R. Gingrich, J. Econ. Entomol. 69: 330 (1976).PubMedGoogle Scholar
  9. 9.
    J.L. Eschle, J.A. Miller, and C.D. Schmidt, Nature 265: 325 (1977).CrossRefGoogle Scholar
  10. 10.
    J.A. Miller, unpublished results.Google Scholar
  11. 11.
    M. Schwarz, R.W. Miller, J.E. Wright, W.F. Chamberlain, and D.E. Hopkins, J. Econ. Entomol. 67: 598 (1974).PubMedGoogle Scholar
  12. 12.
    H. Jaffe, P.A. Giang, and J.A. Miller, in: “Proceedings Symposium on Controlled Release of Bioactive Mat.,” E. Brinkman and J. Montemarano, eds., Gaithersburg, 5. 5 (1978).Google Scholar
  13. 13.
    C. Pitt, Private Communication.Google Scholar
  14. 14.
    C.G. Pitt, D. Christensen, A.R. Jeffcoat, G.L. Kimmel, A. Schindler, M.E. Wall, and R.A. Zweidinger, in: “Proceedings Drug Delivery Systems,” H.S. Gabelnick, ed., DHEW Publication No. (NIH) 77–1238, 141–192 (1976).Google Scholar
  15. 15.
    C.G. Pitt and A. Schindler, in: “Proceedings Symposium on Controlled Release of Bioactive Mat.,” R.W. Baker, ed., New Orleans I - 17 (1979).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • H. Jaffe
    • 1
  • P. A. Giang
    • 1
  • D. K. Hayes
    • 1
  • J. A. Miller
    • 2
  • B. H. Stroud
    • 3
  1. 1.Livestock Insects Laboratory, Agricultural Research, Science and Education AdministrationUSDABeltsvilleUSA
  2. 2.US Livestock Insects Laboratory, Agricultural Research, Science and Education AdministrationUSDAKerrvilleUSA
  3. 3.Animal Operations Unit, Agricultural Research, Science and Education AdministrationUSDABeltsvilleUSA

Personalised recommendations