The quantitative roles of insulin and glucagon in the regulation of hepatic ketogenesis are still not defined adequately. Glucagon added in vitro has been reported by certain workers to stimulate ketogenesis in perfused livers from normal-fed rats (Heimberg, Weinstein, and Kohout, 1969; Weinstein, Klausner, and Heimberg, 1973). However, other workers did not observe a ketogenic effect of the hormone under similar conditions (McGarry and Foster, 1978; McGarry, Wright, and Foster, 1975).
Ketone Body Hormonal Control Perfuse Liver Alloxan Diabetes Hepatic Lipid Metabolism
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Claus, T.H., Pilkis, S.J., and Park, C.R. (1975). Stimulation by glucagon of the incorporation of U-C1’-labelled substrates into glucose by isolated hepatocytes from fed rats. Biochim. Biophys. Acta 404: 110–123.PubMedCrossRefGoogle Scholar
Exton, J.H. and Park, C.R. (1972). Interaction of insulin and glucagon in the control of liver metabolism. pp. 437–455. In R.O. Greep and E.B. Astwood (Eds.) Handbook of Physiology, Section 7, Endocrinology. American Physiological Society, Washington, DC.Google Scholar
Heimberg, M., Van Harken, D.R., Weinstein, I., and Kohout, M. (1969). Regulatory factors in ketogenesis and in the metabolism of tri-glycerides by liver. Adv. Exp. Biol. Med. 4: 185–199.CrossRefGoogle Scholar
Heimberg, M., Weinstein, I., and Kohout, M. (1969). The effects of glucagon, dibutyryl cyclic adenosine 3’,5’-monophosphate and concentration of free fatty acid on hepatic lipid metabolism. J. Biol. Chem. 244: 5131–5139.PubMedGoogle Scholar
McGarry, J.D. and Foster, D.W. (1971). The regulation of ketogenesis by oleic acid and the influence of anti-ketogenic agents. J. Biol. Chem. 246: 6427–6253.Google Scholar
McGarry, J.D. and Foster, D.W. (1978). Hormonal control of ketogenesis. pp. 79–96. In D.M. Klachko, R.R. Anderson, and M. Heimberg (Eds.) Hormones and Energy Metabolism. Plenum Press, New York.Google Scholar
McGarry, J.D., Guest, N.J., and Foster, D.W. (1970). Ketone body metabolism in the ketosis of starvation and alloxan diabetes. J. Biol. Chem. 245: 4382–4390.PubMedGoogle Scholar
McGarry, J.D., Wright, P.H., and Foster, D.W. (1975). Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. J. Clin. Invest. 55: 1202–1209.PubMedCrossRefGoogle Scholar
Seglen, P.O. (1973). Preparation of liver cells. III. Enzymatic requirements for tissue dispersion. Exp. Cell Res. 82: 391–398.PubMedCrossRefGoogle Scholar
Scow, R.O. and Chernick, S.S. (1960). Hormonal control of protein and fat metabolism in the pancreatectomized rat. Rec. Progr. Horm. Res. 16: 497–541.PubMedGoogle Scholar
Scow, R.O. and Chernick, S.S. (1970). Mobilization, transport, and utilization of free fatty acids. Comp. Biochim. 18: 1949.Google Scholar
Weinstein, I., Klausner, H.A., and Heimberg, M. (1973). The effect of concentration of glucagon on output of triglyceride, ketone bodies, glucose and urea by the liver. Biochim. Biophys. Acta 300: 300–309.Google Scholar
Woodside, W.F. and Heimberg, M. (1976). Effects of anti-insulin serum, insulin, and glucose on output of triglycerides and ketogenesis by the perfused rat liver. J. Biol. Chem. 251: 13–23.PubMedGoogle Scholar