Hormonal Control of Ketogenesis

  • J. Denis McGarry
  • Daniel W. Foster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 111)


Interest in how the body regulates its production of the ketone bodies, acetoacetic and β-hydroxybutyric acids, has grown exponentially in recent years both among clinicians and biochemists. The reason stems from the fact that historically these compounds have been associated primarily with pathological disorders, most notably uncontrolled diabetes, where their excessive accumulation in the blood constitutes a life-threatening problem. During the past two decades, however, it has been clearly established that in certain physiological situations a modest elevation in the blood ketone level is crucial to the overall fuel economy of the body (Bailey and Lockwood, 1973; Krebs, 1966; Krebs, Williamson, Bates, Page, and Hawkins, 1971; Owen, Felig, Morgan, Wahren, and Cahill, 1969; Owen, Morgan, Kemp, Sullivan, Herrera, and Cahill, 1967). Nevertheless, despite these major advances a number of fundamental issues concerning the hormonal and biochemical mechanisms involved in the control of the ketogenic process remain to be clarified. In the present paper we shall focus on recent developments that promise to shed new light on this area of metabolic regulation.


Ketone Body Hormonal Control Octanoic Acid Liver Glycogen Carnitine Concentration 
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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • J. Denis McGarry
    • 1
  • Daniel W. Foster
    • 1
  1. 1.Departments of Internal Medicine and BiochemistryUniversity of Texas Health Science CenterDallasUSA

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