Hormonal Regulation of Lipolysis: Role of Cyclic Nucleotides, Adenosine, and Free Fatty Acids

  • J. N. Fain
  • R. E. Shepherd
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 111)


Twenty years ago, Dole (1956) and Gordon and Cherkes (1956) presented evidence that lipid is mobilized from adipose tissue in the form of free fatty acids noncovalently bound to plasma albumin. The fatty acids are taken up by muscle, liver, and other tissues where they are either oxidized as a source of energy or reesterified. In addition, free fatty acids (FFA) may also be converted to ketone bodies by liver and, subsequently, oxidized by muscle and the brain as a source of energy.


Free Fatty Acid Adenylate Cyclase Hormonal Regulation Adenosine Deaminase Triglyceride Lipase 


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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • J. N. Fain
    • 1
  • R. E. Shepherd
    • 1
  1. 1.Section of Physiological Chemistry, Division of Biology and MedicineBrown UniversityProvidenceUSA

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