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Hormonal Control of Hepatic Lipogenesis

  • R. A. Harris
  • J. P. Mapes
  • R. S. Ochs
  • D. W. Crabb
  • L. Stropes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 111)

Abstract

Hepatic lipogenesis is subject to both fine (short-term) and coarse (long-term) control mechanisms. Coarse control, i.e., adaptive change in enzyme quantity, is recognized as being important for nutritional and hormonal control of lipogenesis (for reviews see Gibson, Lyons, Scott, and Muto, 1972; Goodridge, 1975; Lakshmanan, Nepokroeff, and Porter, 1972; Numa and Yamashita, 1974). Hepatic enzymes of lipogenesis which appear to respond to this mode of regulation include acetyl-CoA carboxylase (E.C. 6.4. 1.2), fatty acid synthetase system, stearyl CoA desaturase system, glucokinase (E.C. 2.7.1.2), glucose-6-phosphate dehydrogenase (E. C. 1.1.1.49), pyruvate kinase (E.C. 2.7.1.40), phosphofructokinase (E.C. 2.7.1.11), and the citrate cleavage enzyme (E.G. 4.1.3.8), and malic enzyme (E.C. 1.1.1.38).

Keywords

Pyruvate Kinase Fatty Acid Synthesis Hormonal Control Aerobic Glycolysis Fatty Acid Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • R. A. Harris
    • 1
  • J. P. Mapes
    • 1
  • R. S. Ochs
    • 1
  • D. W. Crabb
    • 1
  • L. Stropes
    • 1
  1. 1.Department of BiochemistryIndiana University School of MedicineIndianapolisUSA

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