Effect of Age on Kidney Hyperplasia in the Rat after Unilateral Nephrectomy
Adaptive growth of the mammalian, kidney after nephrectomy of the contralateral organ is a firmly established phenomenon. Both increase in cell size and cell number take part in the compensatory growth and the greatest changes appear in kidney cortex. It is not clear, however, whether some ontogenetic differences in renal growth after unilateral nephrectomy exist, as there is evidence pro as well as contra the relation between the age of the individual and the degree and character of kidney growth and restoration of normal function (1–4). Therefore we studied the main characteristics of kidney growth after unilateral nephrectomy in very young, adult and ageing, but not yet senile, rats comparing kidney weight and number of cells obtained from the kidney by trypsinization.
KeywordsCompensatory Growth Kidney Cortex Kidney Weight Unilateral Nephrectomy Renal Growth
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