The Role of Retinol in, and the Action of Anti-Inflammatory Drugs on, Hereditary Retinal Degeneration
Inherited retinal dystrophy in the rat is transmitted by an autosomal recessive gene and blindness occurs after birth as a result of degeneration of the photoreceptor cells (1,2). This resembles the situation in certain forms of inherited retinitis pigmentosa in man. Degeneration of the retina in the strain of albino dystrophic rats known as “Campbells” (1) is associated with an increase in the level of “free” lyric enzymes which appear to originate from lysosomes in the adjacent pigment epithelium (3). It has been suggested (4) that the degeneration of the visual cells is produced by breakdown of lysosomal membranes in pigment epithelium and retina. This breakdown is thought to be due to an abnormal build up of vitamin A alcohol (retinol) in the pigment epithelium which arises from the action of light on an unusually labile type of visual pigment (5).
KeywordsAcetylsalicylic Acid Lysosomal Enzyme Visual Pigment Retinal Degeneration Retinal Dystrophy
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