Fat Cells in Ontogenesis

  • Ludmila Kazdová
  • Pavel Fábry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


In recent years it was revealed that in adipose tissue active cell proliferation and an increase of cell number takes place; this process participates in a significant way in the increase of adipose tissue mass during ontogenetic development (1–4). The growth of adipose tissue by hyperplasia of adipocytes can be stimulated in growing animals by some nutritional stimuli, which include refeeding, after previous fasting (5) or hyperphagia in the early postnatal period (6,7). In recent years we studied intensely this induced hyperplasiaof adipose tissue and found that in the mechanism of triggering of DNA synthesis insulin may play a role, similar to the role it plays in some other tissues (8–11). We have demonstrated that the administration of small doses of insulin for 24–72 hr leads to an increase of DNA content of adipose tissue. After isolation of cellular and subcellular fractions fron adipose tissue we found that insulin stimulated the synthesis of nuclear and not of nitochondrial DNA and caused increased proliferation of fat and stromavascular cells. In keeping with this was also the increase in the number of fat and stromavascular cells ascertained by calculation and histological examination of tissue, when cells in mitotic division were found as well as an increased ratio of smaller adipocytes (12–14).


Adipose Tissue Postnatal Development Adipose Tissue Mass Adipose Tissue Blood Flow Nutritional Stimulus 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Ludmila Kazdová
    • 1
  • Pavel Fábry
    • 1
  1. 1.Research Centre of Metabolism and Nutrition of the Institute for Clinical and Experimental MedicinePragueCzechoslovakia

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