Advertisement

On the Ageing of Intermitotic Cells — Investigations on Enterocytes and Hepatocytes

  • G. Leutert
  • W. Rotzsch
  • W. Beier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)

Abstract

At first, we think, it is necessary to define ageing. Ageing in the sense of Max Burger (1) reflects the physiological, morphological, biochemical and biophysical changes, which occur during the life-span of an individual. These changes are arranged into changes during prenatal development, postnatal development, adolescence and senescence. Ageing takes place at different levels; at the level of the organism, organ and tissue, which includes cells and intercellular substance. The ageing changes are underlying changes at the different levels, because the parts of the organism, its organs, tissues and cells, are aging disproportionately. For that reason the cell represents only one level, but a very important one. Many of the hypotheses now being discussed, put the changes of the cell into the center of consideration. Doubtless there is an ageing process of postmitotic cells concerning lipofuscin, mitochondria, lysosomes, molecular arrangements between DNA and histones, contents of RNA and pattern of enzymes. But it is questionable up to now: Is there an ageing process of intermitotic cells too? At first we have to distinguish between ageing processes starting in single cells and such starting in multicellular arrangements on the level of tissues.’ The single cell shows changes during its cell cycle. But it is questionable, if there is a difference in the view of rise, maturation and death of intermitotic cells between young and old individuals.

Keywords

Ageing Process Postnatal Development Cell Renewal Prenatal Development Biological Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Burger, M. Altern und Krankheit. 1. Aufl, VEB Georg Thieme Leipzig, 1947.Google Scholar
  2. 2.
    Verzâr, F. 1971. Physiologie und Gerontologie. Zschr. F. Alternsf, 24: 209.Google Scholar
  3. 3.
    Verzâr, F. 1972. Regulation of adaptation processes in the mechanism of ageing. Vortrag, gehalten auf d.9.Internat., Kongreß für Gerontologie in Kiew, 2.-7. 7.Google Scholar
  4. 4.
    Hahn, H.P.v. 1969. Genetische Faktoren im cellulär.en. Alternsprozess. Bull,d.Schweiz,Akad,d.Med.Wiss. Bd, 24: 272.Google Scholar
  5. 5.
    Holle, G. 1972. ‘Probleme der gegenwärtigen Alternsforsehung. In: Handb.d.allg.Path.,, 6.Bd., 4.Teil, 1, Springer BerlinHeidelberg-New York.Google Scholar
  6. 6.
    Strehler, B. I. 1962. Time; Cells and aging. Academic Press, New York.Google Scholar
  7. 7.
    Comfort, A. 1964. Ageing. The biology of senescence. Routledge & Paul, Kegan, LondonGoogle Scholar
  8. 8.
    Bertalanffy, F.D. 1962. Cell renewal in the gastrointestinal tract of man. Gastroenterol. 43: 472.Google Scholar
  9. 9.
    Bertalanffy, F.D. 1963. Aspects of cell formation and exfoliation related to cytodiagnostic, Act. Cytol. 7: 362.Google Scholar
  10. 10.
    Rother, P., Scheller, G., Hellthaler, G. and Dähnert, K. 1971. Uber die Rhythmik, die Dauer und die Häufigkeit von Mitosen im Dünndarmepithel der Ratte. Zeitschr.f.mikr.-anat.Forsch. 83: 399.Google Scholar
  11. 11.
    David, H. 1967. Zum Mechanismus der Zellabsto8ung im’ Bereich der Dünndarmzotten. Virch.Arch.Path.Anat. 342: 19.Google Scholar
  12. 12.
    Tews, K., Jahn, K. and Leutert, G. 1971. Baustein-histochemische Studien am Dünnlarmepithel von Ratten verschiedenen Alters. Zschr.mikr.-anat.Forsch. 83: 423:PubMedGoogle Scholar
  13. 13.
    Leutert, G., Jahn, K. and Weise, K. 1973. Altersabhängige Veränderungen der Enzymaktivitäten von Enterozyten -histochemische Untersuchungen. Zeitschr.f.Alternsf. 26: 375.Google Scholar
  14. 14.
    Hellthaler, G., Kähler, H. and Rotzsch, W. 1971. Altern-« sabhängige Veranderungen bei Proteinsynthese von Dünndarm-ringen. Zeitschr.f:Alternsf. 24: 243.Google Scholar
  15. 15.
    Leutert, G. and Brandt, E. Morphometrische Untersuchungen Zeitschr.f.Alternsforsch. (im Druck).Google Scholar
  16. 16.
    Mitroiu, P., Lang, W. and Maurer, W. 1968. Autoradiographische Bestimmung des Markierungsindex, der S-Phase und der Gener-ationszeit einiger Zellarten von 2 bis 35 Tage alten Kuken.. Z.Zellf. 90: 68.CrossRefGoogle Scholar
  17. 17.
    Heim, F., Schwarzlose, W., Truckenbrodt, H. and Mizznegg, P. 1969. Desoxyribonukleinsäure-, Ribonukleinsäure-und Eiweißgehalt, Zellneubildung und Zellgröße in Abhängigkeit von Alter,’ Geschlecht und Ernährung und deren Beeinflussung durch anabole und antianabole Stoffe. Zeitschr.f.Geront. 2: 25.Google Scholar
  18. 18.
    Richter, V. and Rotzsch, W. 1972/1973. Turnover of rat liver and rat kidney catalase as a function of age. Mech. Age. Dew. 1: 427.CrossRefGoogle Scholar
  19. 19.
    Adelman, R.C. 1971. Age dependence effects in enzyme induction“ a biochemical expression of aging. Exp. Ger. 6: 75.CrossRefGoogle Scholar
  20. 20.
    Wiegel,D., Beier, W. and Brehme, K.-H. 1973. Vitality and error rate in biological systems: Some theoretical considerations. Mech. Age. Dev. 2: 117.CrossRefGoogle Scholar
  21. 21.
    Orgel, L.E. 1963. The maintenance of accuracy of protein synthesis and its relevance to ageing. Proc. Nat, Acad. Sci., USA 49: 517CrossRefGoogle Scholar
  22. 22.
    Beier, W., Rotzsch, W., Leutert, G. and Ries, W. 1970. Zur Molekularbiologie des Alterns. 2. Mitteilung: Ein mathe-matisches Modell des Alterns eines multizellulären Systems. Zeitschr.f.Alternsf. 22: 333.Google Scholar
  23. 23.
    Beier, W., Brehme, K.-H. and Wiegel, D. 1973, Biophysikalische Aspekte des Alterns’multicellulärer Systeme. Fortschritte der theoretischen und experimentellen Biophysik, Heft 16, VEB Georg Thieme, Leipzig.Google Scholar
  24. 24.
    Shock, N.W. 1961. Physiological aspects of ageing in man. Am. Rev. Physiol. 23: 97.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • G. Leutert
    • 1
  • W. Rotzsch
    • 1
  • W. Beier
    • 1
  1. 1.Karl-Marx-UniversitätLeipzigGermany

Personalised recommendations