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Studies on the Glucocorticoid Receptor and the Hormonal Modulation of the mRNA for Tryptophan Oxygenase

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Hormone Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 96))

Abstract

The important role played by steroid hormones in development and physiological regulation in animals has led investigators over the past few decades to attempt to unravel and understand the molecular mechanisms involved in the function of steroid hormones. Several studies have shown that the steroid hormones, including the glucocorticoid hormone, bind with high affinity to specific receptor proteins in the target cell cytoplasm. The glucocorticoid-receptor complex has been shown to undergo an alteration to an “activated” state which has high affinity for chromosomal sites within the cell nucleus. This glucocorticoid-receptor interaction with the genome accompanies, and is presumed to be responsible for, the cellular responses characteristic of the hormone and its target tissues. The receptor proteins promise to be useful probes in understanding genetic control mechanisms and also the organization and structure of the eukaryotic chromosomes.

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Authors and Affiliations

  1. Institute of Cancer Research & Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA

    Leelavati Ramanarayanan-Murthy, Paul D. Colman & Philip Feigelson

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  1. Leelavati Ramanarayanan-Murthy
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  2. Paul D. Colman
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  3. Philip Feigelson
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Editors and Affiliations

  1. University of Missouri-Columbia, USA

    David M. Klachko M.D. (Associate Professor of Medicine), Leonard R. Forte Ph.D. (Associate Professor of Pharmacology) & John M. Franz Ph.D. (Associate Professor of Biochemistry) (Associate Professor of Medicine),  (Associate Professor of Pharmacology) &  (Associate Professor of Biochemistry)

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Ramanarayanan-Murthy, L., Colman, P.D., Feigelson, P. (1978). Studies on the Glucocorticoid Receptor and the Hormonal Modulation of the mRNA for Tryptophan Oxygenase. In: Klachko, D.M., Forte, L.R., Franz, J.M. (eds) Hormone Receptors. Advances in Experimental Medicine and Biology, vol 96. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0722-9_3

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  • DOI: https://doi.org/10.1007/978-1-4757-0722-9_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0724-3

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