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A Further Investigation into the Mechanisms Underlying the Kindling Phenomenon

  • R. Racine
  • J. Zaide

Abstract

For many of us who work on the kindling phenomenon, there is often some ambiguity about our intentions. Are we investigating a learning model or an epilepsy model? Most neuroscientists would agree that claims of a relationship between epilepsy and learning are risky, to say the least. Consequently, we usually play it safe by using terms such as neural plasticity, or we focus on kindling as an epilepsy model. There is at least a little psychologist in all of us however, and that part of us would like to “solve” learning. We have been rather disappointed by recent data that seemed to us to be inconsistent with a learning model view of the kindling. In this paper we will review some of the work that led to an increasing skepticism about the validity of kindling as a learning model, and then we will describe some of our most recent work. This work, we believe, suggests that it may be premature to give up on the relevance of kindling to learning.

Keywords

Excitatory Response Secondary Site Perforant Path Acute Experiment Conditioned Emotional Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. ARNOLD, P., RACINE, R., WISE, R. Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat. Experimental Neurology, 1973, 40, 457–470.PubMedCrossRefGoogle Scholar
  2. BLISS, T.V.P. and LOMO, T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. Journal of Physiology (London), 1973, 232, 331–356.Google Scholar
  3. BAOST, C.A. and McINTYRE, D.C. Bilateral kindled amygdala foci and inhibitory behaviour in rats: a functional lesion effect. Physiology and Behaviour, 1977, 18, 25–28.CrossRefGoogle Scholar
  4. BURNHAM, W.M. Primary and “transfer” seizure development in the kindled rat. Canadian Journal of Neurological Science, 1975, 2, 417–428.Google Scholar
  5. CALLAGHAN, D.A. and SCHWARK, W.S. Neurochemical changes and drug effects in a model of epilepsy in the rat. Society for Neuroscience, Sixth Annual Meeting. Toronto, Canada, 1976.Google Scholar
  6. CALVIN, W. and SYPERT, G. Cerebral cortex neurons with extra spikes: a normal substrate for epileptic discharges. Brain Research, 1975, 83, 498–503.PubMedCrossRefGoogle Scholar
  7. CRAGG, B. Changes in visual cortex on first exposure of rats to light. Nature, 1967, 215, 251–253.PubMedCrossRefGoogle Scholar
  8. CURTIS, D.R. and ECCLES, J.C. Synaptic action during and after repetitive stimulation. Journal of Physiology (London), 1960, 150, 374–398.Google Scholar
  9. DOUGLAS, R.M. Long-lasting perforant path potentiation with very brief tetanic bursts. Society for Neuroscience, Sixth Annual Meeting. Toronto, Canada, 1976.Google Scholar
  10. ECCLES, J.C. Possible ways in which synaptic mechanisms participate in learning, remembering and forgetting. In D.P. Kimble (Ed.), The Anatomy of Memory. Science and Behaviour Books, Palo Alto, 1965. pp 12–87.Google Scholar
  11. ECCLES, J.C. and RALL, W. Effects induced in a monosynaptic reflex path by its activation. Journal of Neurophysiology, 1951, 14, 353–376.PubMedGoogle Scholar
  12. FIFKOVA, E. and VAN HARREVELD, A. Differential effect of stimulation of the perforant and commisural path on axon terminals and dentritic spines of the dentate molecular layer. Society for Neuroscience, Sixth Annual Meeting. Toronto, Canada, 1976.Google Scholar
  13. FLEXNER, L.B., FLEXNER, J.B. and ROBERTS, R.B. Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning. Proceedings of the National Academy of Science, United States, 1966, 56, 730–735.Google Scholar
  14. GODDARD, G.V. Functions of the amygdala. Psychological Bulletin, 1964, 62, 89.PubMedCrossRefGoogle Scholar
  15. GODDARD, G.V. and DOUGLAS, R.M. Does the engram of kindling model the engram of long term memory? Canadian Journal of Neurological Science, 1975, 2, 385–394Google Scholar
  16. GODDARD, G., McINTYRE, D. and LEECH, C. A permanent change in brain function resulting from daily electrical stimulation, Experimental Neurology, 1969, 25, 295–330PubMedCrossRefGoogle Scholar
  17. GREENOUGH, W. and VOLKMAR, F. Pattern of dentritic branching in occipital cortex of rats reared in complex environments. Experimental Neurology, 1973, 40, 491–550PubMedCrossRefGoogle Scholar
  18. JASPER, H.H., WARD, A.A. and POPE, A. (Eds,). Basic Mechanisms of the Epilepsies. Little, Brown and Co., Boston, 1969Google Scholar
  19. LEECH, C.K. Rate of development of electrically kindled convulsions compared to audiogenic seizures and learning ability in six inbred mouse strains. Unpublished Ph.D. thesis, University of Waterloo, 1972.Google Scholar
  20. LEECH, C.K. and McINTYRE, D.C. Kindling rates in inbred mice: An analog to learning.? Behavioural Biology, 1976, 16, 439–452.CrossRefGoogle Scholar
  21. LIDSKY, T.I., LEVIN, M.S., KREINICK, C.J. and SCHWARTZBAUM, J.S. Retrograde effects of amygdaloid stimulation on conditioned suppression (CER) in rats. Journal of Comparative and Physiological Psychology, 1970, 73, 135–149.PubMedCrossRefGoogle Scholar
  22. McINTYRE, D.C. and GODDARD, G.V. Transfer, interference and spontaneous recovery of convulsions kindled from the rat amygdala. Electroencephalography and Clinical Neurophysiology, 1973, 35, 533–543.PubMedCrossRefGoogle Scholar
  23. McINTYRE, D.C. and MOLINO, A. Amygdala lesions and CER learning: Long term effect of kindling. Physiology and Behaviour, 1972, 8, 1055–1058.CrossRefGoogle Scholar
  24. McNAUGHTON, B.L. and BARNES, C.A. Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant paths. Society for Neurosciences, Sixth Annual Meeting. Toronto, Canada, 1976Google Scholar
  25. MOLLAARD, K., DIAMOND, M., BENNETT, E., ROSENZWEIG, M. and LINDNER, B. Quantitative synaptic changes with differential experience in rat brain. International Journal of Neurosciences, 1971, 2, 113–128.CrossRefGoogle Scholar
  26. MOORE, R., BJORKLUND, A. and STENEVI, U. Growth and plasticity of adrenergic neurons. In Schmitt, F. and Worden, F. (Eds.), The Neurosciences–Third Study Program. MIT Press, Boston, 1974. pp. 961–977.Google Scholar
  27. ORRELL, F., TSURU, N., HOEPPNER, T.J., MORGAN, D. and HARRISON, W. Secondary epileptogenesis in frog forebrain: effect of inhibition of protein. Canadian Journal of Neurological Science, 1976, 2, 407–416.Google Scholar
  28. RACINE, R. Modification of seizure activity by electrical stimulation: I. Afterdischarge threshold. Electroencephalography and Clinical Neurophysiology, 1972a, 32, 281–294.PubMedCrossRefGoogle Scholar
  29. RACINE, R. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalograph and Clinical Neurophysiology, 1972b, 32, 281–294.CrossRefGoogle Scholar
  30. RACINE, R. Modification of seizure activity by electrical stimulation: Cortical areas. Electroencephalography and Clinical Neurophysiology, 1975, 38, 1–12.PubMedCrossRefGoogle Scholar
  31. RACINE, R., BURNHAM, W. and GARTNER, J. First trial motor seizures triggered by amygdaloid stimulation in the rat. Electroencephalography and Clinical Neurophysiology, 1973, 35, 487–494.PubMedCrossRefGoogle Scholar
  32. RACINE, R., NEWBERRY, F. and BURNHAM, W. Post-activation potentiation and the kindling phenomenon. Electroencephalograph and Clinical Neurophysiology, 1975, 39, 261–271.CrossRefGoogle Scholar
  33. RACINE, R., TUFF, L. and ZAIDE, J. Kindling, unit discharge patterns, and neural plasticity. Canadian Journal of Neurological Sciences, 1975b, 2, 395–406.PubMedGoogle Scholar
  34. RAISMAN, G. Neuronal plasticity in the septal nuclei of the adult rat. Brain Research, 1969, 14, 25–48PubMedCrossRefGoogle Scholar
  35. RANCK, J.B., Jr. Studies on single neurons in dorsal hippocampal formation and septum in unrestricted rats. Part 1. Behavioural correlates and firing repertories. Experimental Neurology, 1973, 41, 461–531.PubMedCrossRefGoogle Scholar
  36. ROBERTS’ L. and WRIGHT, M. Operant autonomic conditioning in paralyzed rats. Technical report No. 60. Department of Psychology, McMaster University, Hamilton, Ontario, 1374.Google Scholar
  37. RUTTLEDGE, L., WRIGHT, C. and DUNCAN, J. Morphological changes in pyramidal cells of mammalian cerebral cortex associated with increased use. Experimental Neurology, 1974, 44, 209–228.CrossRefGoogle Scholar
  38. SATO, M. and NAKASHIMA, T. Kindling: Secondary epileptogenesis, sleep and catecholamines. Canadian Journal of Neurological Sciences, 1975, 2, 439–446.PubMedGoogle Scholar
  39. TAPP, J.T. Strain differences in the acquisition of a conditioned emotional response. journal of Comparative and Physiological Psycboloay, 1964, 57, 464–465.Google Scholar
  40. VALVERDE, D. Rate and extent of recovery from dark rearing in the mouse. Brain Research, 1971, 33, 1–11.PubMedCrossRefGoogle Scholar
  41. WEST, D. and GREENOUGH, W. Effect of environmental complexity on cortical synapses of rats: Preliminary results. Behavioural Biology, 1972, 7, 279–284.CrossRefGoogle Scholar
  42. WALTERS, D.J. Sporadic interictal discharges in kindled epïlaytogeoio foci. Unpublished M.A. thesis. Dalhousie University. 1970.Google Scholar
  43. ZAIDE, J. Differences between Tryon bright and dull rats in seizure activity evoked by amygdala stimulation. Physiology and Behaviour, 1974, 12, 527–534.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • R. Racine
  • J. Zaide

There are no affiliations available

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