Abstract
The audacious hypothesis of Papez, who in 1937, related emotion to the neural substrate that is now called mesial limbic, has been verified in the last forty years by increasingly abundant evidence. Subsequently the contributions made by Yakovlev, Nauta, McLean, Jones and Powell, Pribram and Livingston have provided a detailed understanding of the fine neuroanatomical structure and of the neurophysiological organization of the mesial and basolateral components of the limbic system. In its essential structure this is constituted by the convergence of the sensory cortical systems in the orbital and superior temporal gyri projecting then into the amygdaloid, hypothalamic and brain-stem limbic core, on the one hand and into the cingulum, hippocampal-fornix, mamillo-thalamic tract, feeding back into the cingulum and the mesial-orbital frontal regions, on the other. Yakovlev and Nauta have emphasized that the orbital frontal limbic cortex is defined by the dorso-medial nucleus of the thalamus and also stressed the importance of complex cingulate-frontal, cingulate-striatal and orbital striatal connections. McLean, in 1952, proposed that the expanded Papez mesial limbic circuit be called the “limbic system”, as by then the extreme importance of its basolateral component, notably the orbital frontal anterior temporal circuit was well understood. Nauta has also shown how the anterior cortical limbic structures are linked to the mesencephalic limbic core through the medial forebrain bundle which bifurcates to the septal and the amygdaloid nuclei. Nauta has further concluded that the relation of the frontal limbic zone, to the rest of the limbic system, is such that it might be viewed as the regulator of the limbic system as a whole — which it modulates. McLean, on the basis of neurophysiological studies, observed with others, that the orbital limbic region contained within its boundaries the highest representation of autonomic activity and he also developed a functional dichotomy in the organization of the anterior limbic system: a mesial-septal system relating principally to sexuality and to “preservation of the species” and a lateral amygdaloid system relating to defence and “preservation of the individual”. Impressed by the common symptomatology encountered in temporal seizures, in limbic encephalitis and in the endogenous psychoses, McLean considered that perturbation of the fronto-temporal limbic regions might be responsible for the perceptual, ideational and mood abnormalities that characterize the functional psychoses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
ANNETT, M. (1967). The binominal distribution of right, mixed and left handedness. Q. Exp. Psychol. 19: 327–333.
DAZ8IN, E.F., WASSERMAN, L.I. 6 T0NK0N0GII, I.M. (1975), Auditory hallucinations and left temporal lobe pathology. Neuropsychologia, 13: 481–487.
BOKLAGE, C.E. (1974). Embryonic determination of brain programming asymmetry: A neglected element in twin-study genetics of human mental development. Proceedings of the First International Congress of Twin Studies. Gregor Mental Institute for Medical Genetics and Twin Studies, Rome, Italy.
BOKLAGE, C.E. (1976). Schizophrenia, brain asymmetry development, and twinning: Cellular relationship with etiological and possibly prognostic implications. In press: Biol. Psych.
CHAPMAN, J. (1966). The early symptoms of schizophrenia. Brit. J. Psychiat., 112: 226–251.
FITZGERALD, G. 6 STENGEL, B. (1945). Vestibular reactivity to caloric stimulation in schizophrenics. Preliminary Report. J. 0eot, Sci., 91: 93–100.
FU]R-HENRY, P. (1076). Epilepsy and psychopathology. In “Recent Advances in Clinical Psychiatry.” Chapt. 10: 262–205. Eú. Granville-Grossman, Churchill Livingstone, Edinburgh.
FLOR-HENRY, P. (1076). Lateralized temporal-limbic dysfuoctïon and psychopathology. In Symposium of New York Academy of Sciences, “Origin and Evolution of Language and Bpeecb.” In press, Proceedings.
FCOD-HENRY, P. (1074). Psychosis, neurosis and epilepsy. Br. J. Psychiat., 124: 144–150.
FL0K-HENRY, P. (1969). Psychosis and temporal lobe epilepsy. A controlled investigation. Epilepsia, 10: 363–395.
FLOR-HENRY, P., K0LES, Z.J., B0–LASS8N P. and YEUDALL, L.T. (1975). Studies of the functional psychoses: Power spectral EEG Ana- lysis. IRCS Med. Sci. 3: 87.
FLOR-HENRY, P., KOLES, Z.J. 6 YEUDALL, L.T. (1977). Psychoses: Spectral and neuropsychological study. In press, Sixth World Congress of Psychiatry (Abstracts).
FL0R-HENRY, P. and LAMPRECHT, F. (1976). Generalized seizures, limbic seizures, forced normalization and psychosis: Forced normalization and the problem of the antithetical relationship between epilepsy and psychosis. Proceedings of the Seventh International Symposium on Epilepsy, Ed. D. Janz, Georg Thieme, Stuttgart, 80. 90.
FLOR-HENRY, P., YEUDALL, L.T., STEFANYK, W. and HOWARTH, B. (1975). The neuropsychological correlates of the functional psychoses, IRCS Med. Sci. 3: 34.
GAINOTTI, G. (1972). Emotional behaviour and hemispheric side of the lesion. Cortex, 8(1): 41–55.
GESCHWIND, N. (1964). Non-aphasic disorders of speech. Int. J. Neurol. 4: 207–214, Reprinted in “Selected Papers on Language and the Brain”. 1974. N. Geschwind, Sd, 549. Synthese Library; D. Redel Publishing Co.’ Dordrecht, Holland.
GOLDSTEIN, L., SUGERMAN, A.A., STOLBERG, H., MURPHRIE, 8.B. ~ PFEIFFER, C.C. (1965). Electro-cerebral activity in schizophrenics and non-psychotic subjects: quantitative EEG amplitude analysis. Electroencephalogr. Clio. Neurophysiol. 19: 350–361.
GREGORIADIS, and., FRAGOS, E., KAPSALAKIS, Z. and MANDOUVALOS, B. (1971). A correlation between mental disorders and EEG and AEG findings in temporal lobe epilepsy. Abstracts, Fifth World Congress of Psychiatry, La Prensa Medica Mexicana, Mexico. p. 325.
GRUZELIER, J.H. (1973). Bilateral asymmetry of skin conductance orienting activity and levels in schizophrenics. Biol. Psychol. 1: 21–41.
GRUZELIER, J. and VENABLES, P. (1974). Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenia: repli-cation and evidence of lateral asymmetry in patients with depression and disorders of personality. Biol. Psychiatry, 8(1): 6S-73
GRUZELIER, J.H. and VENABLES’ P.H. (1973). Skin conductance responses to tones with and without attentional significance in schizophrenic and nonschizophrenic psychiatric patients. Neuropsychologia, 11: 221–230.
HECAEN, H., de AJURIAGUERRA, J. (1952). Meconnaissances et hulluccinations corporelles. Mason and Cie, Paris, France.
HOMMES, O.R. and PANHUYSEN, L.8.(1970) Depression and cerebral dominance. A study of bilateral intracarotid amytal in eleven depressed patients. Psychiatr. 0ourol. Neurocbir. 74: 259–270.
INGVAR, D.H. and FRANZEN, G. (1974). Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr. 8cuod, 50: 425–562
JONES, E.G. and POWELL, T.P.S. (1970). An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 93: 793–820.
KLEIST, K. (1928). Ober zykloid, paranoid und epileptoide Psychosen und uber die Frage der Degenerationspychosen. Schweiz, Arcb, Neurol. Psychiatr. 23: I-36. In “Themes and Variations in European Psychiatry”, S.K. Hirsch and M. Shepherd, Eds. Traosl. by H. Marshall. Chapt. 12: 295–331. John Wright ú Sons Ltd. Bristol, 5ngluod
KLEIST, K. (1960). Gcbizopbreoïc symptoms and cerebral pathology. J. Ment. Sci. 106: 246–255.
KOH, S.D., KAYTON, L. and GIRGIKEK, S.K. (1976). Short term memory for numerousness in schizophrenic yound adults, J. Nerv. and Mont. Dis. 163: 88–10I.
KOLES, Z.J. and FLOR-HENRY, P. (1976). The task-dependence of the electroencephalogram in normal and schizophrenic subjects. Digest of Eleventh Conference on Medical and Biological Engineering, Ottawa. p. 220–221.
LANGE, S.C., JULIEN, R.M. and FOWLER, G.W. (1976). Biphasic effects of imipramine in experimental models of epilepsy. Epilepsia, 17: 183–196.
LIG0M\N, W.A. (1968). Brain damage in relation to psychiatric dis- ability after head injury. Br. J. Psychiat. 114: 373–410.
LISHMAN, W.A. and McMEEKAN, E.R.L. (1976). Hand preference patterns in psychiatric patients. Brit. J. Psychiat. 129: 158–166.
LIVINGSTON, K.E. (1975)’ Surgical contributions to psychiatric treatment. In “American Handbook of Psychiatry”, 2nd Gd, Ed: D.X. Freedman and J.E. Dyrud, Cahpt. 28. Basic Books, Inc.
LIVINGSTON, K.B. and ESCOBAR, A. (1971), Anatomical bias of the limbic system concept: A proposed reorientation. Arch. Neur. 24: 17–21.
MacLEAN, P.D. (1949). Psychosomatic disease and the “visceral brain”; Recent Developments Bearing on Papez Theory of Emotion. Psycbosom, Med. 11(6): 338–353.
MacLean, P.D. (1952). Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (visceral brain). Electroencephalogr. Clin. Neurophysiol. 4: 407–4I8.
MacLEAN, P.D. (1970). The limbic brain in relation to the psychoses. In “Physiological Correlates of Emotion”. Ed. P. Black. Chapt. 7: 129–146. Academic Press, New York, N.Y.
MILNER, B. Quoted in ROSSI, G.F. and ROSAD[MI, G. Opus cited.
MJKBIN, S.S. and DINABOURG, E.Y. (1965). Epileptiform manifestations in early right-sided and left-sided lesions of the brain in cbi1dzon_ Zh. Nevropatal.Psikhiatr. im S.S. Korsakova, 65: 1074–1077.
MONAKHOV, K.K. (197I). The Pavlovian theory in psychiatry, some recent developments. In “Modern Perspectives in World Psychiatry”. Ed. J.G. Howells, 531–556. Transi. Dr. R. Pos. Brunner Mazel, New York, N.Y.
MOON, A.F., MEFFERD, R.B., WIELAND, B.ú., POKORNY, A.D. and FALCONER, G.A. (1968). Perceptual dysfunction as a determinant of schizophrenic word associations, J. Ner. Mont. Dïs, 146(1): 80–84.
NAUTA, W.J.H. (1973). Connections of the frontal lobe with the limbic system. In “Surgical Approacbes in Psychiatry”, Chapt. 39, 303–314, Ed. L.V. Laitinen and K.E. Livingston, Medical and Tocboical Publishing Co. Ltd., Lancaster, Eng.
NAUTA, W.J. (1971). The problem of the frontal lobe, a reinterpretation. J. Psychiat. Res. 8: 167.
PAPEZ, J.W. (1937). A proposed mechanism of emotion. Arch. Neurol. Psychiatry 38: 725–743.
POWELL, T.P.S. (1973). Sensory convergence in the cerebral cortex. In “Surgical Appröaches in Psychiatry”, Eds. L.V. Laitinen and K.E. Livingston. Chapt. 36: 266–281. Medical and Technical Publishing Co. Lancaster, Eng.
PRIBRAM, K.H. (1967). The limbic systems, efferent control of neural inhibition and behaviour. In “Progress in Brain Research.”
Eds. W.R. Adey and T. Tokizane. Vol. 27: 318–336. American Elsevier Publishing Co. New York, N.Y.
ROSSI, G.F. and ROSADINI, G. (1967). Experimental analysis of cerebral dominance in man. In “Brain Mechanism Underlying Speech and Language”, Ed. F.L. Darley, p. 167–184. Grune and Stratton, New York and London.
SCHREIBER, D.J., GOLDMAN, 8., KLEINMAN, K.M., GOLDFADER, P.R. and SNOW, M.Y. (1976). The relationship between independent neuro-psychological and neurological detection and localization of cerebral impairment. J. Nerv, Ment. Dis. 162: 360–365.
SNYDER, S.H. (1976). The dopamine hypothesis of schizophrenia: focus on the dopamine receptor. Am. J. Psychiatry, 133: 197–202.
TandYI0D, D.C. (1975). Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy. Psychological Medicine 5: 249–254.
TAYLOR, Q.C. (1972). Mental state and temporal lobe epilepsy. A correlative account of 100 patients treated surgically. Epilepsia, 13: 727–766.
VINAR, J. and SKALICKOVA, O. (1965). Neurologieke Hedneceni Schizofrenniho Onemoeneni. Cesk. Psychiatr. 61: 373–377.
YAKOVLEV, P.I. (1948). Motility, behaviour, and brain: Stereo-dynamic organization and neural co-ordinates of behaviour. J. Nezv, Ment. Dis. 107: 313–335.
YAKOVLEV, P.I. and LOCKE, S. (1961). Corticocortical connections of the anterior cingulate gyros: the cingulum and subcallosal bundle. Transactions: Am. Neur. Assn. 86: 252–256.
YAKOVLEV, P.I. and LOCKE, S. {1961}. Limbic nuclei of thalamus and connections of limbic cortex. Arch. Neur. 5: 364–400.
ZANGWILL, 0.L. (1964). Psychopathology of dementia. Proc. Roy. Soc. Med. 57: 914–917
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Science+Business Media New York
About this chapter
Cite this chapter
Flor-Henry, P. (1978). The Endogenous Psychoses: A Reflection of Lateralized Dysfunction of the Anterior Limbic System. In: Livingston, K.E., Hornykiewicz, O. (eds) Limbic Mechanisms. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0716-8_16
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0716-8_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0718-2
Online ISBN: 978-1-4757-0716-8
eBook Packages: Springer Book Archive