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Conditioning pp 213-222 | Cite as

Synaptic Plasticity Underlying the Cerebellar Motor Learning Investigated in Rabbit’s Flocculus

  • Masao Ito
Part of the Advances in Behavioral Biology book series (ABBI, volume 26)

Summary

An old concept that the cerebellum is equipped with capabilities of motor learning has been substantiated by recent theoretical exploration of neuronal network models of the cerebellum and by experimental investigation of adaptive motor phenomena which involve the cerebellum. The cerebellar flocculus is inserted into the oculomotor system as a sidepath of the vestibulo-ocular reflex (VOR) arc, and it also receives visual information. It has thus been hypothesized that the flocculus is the site of adaptive modification of the VOR which takes place under visual-vestibular interaction. This flocculus hypothesis of the VOR control has been supported by lesion experiments and by recording impulse signals from flocculus Purkinje cells. Marr-Albus’ modifiable neuronal network model of the cerebellum predicts that this flocculus action is effected through plastic modifiability of synaptic transmission from granule cells to Purkinje cells in the flocculus cortex. The prediction has been substatiated by recent demonstration of a long-lasting depression at granule cell-Purkinje cell synapses after conjunctive stimulation of visual and vestibular inputs to the flocculus.

Keywords

Purkinje Cell Mossy Fiber Parallel Fiber Inferior Olive Climbing Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albus, J.S. (1971) A thoery of cerebellar function. Math. Biosci. 10, 25–61.CrossRefGoogle Scholar
  2. Dufossé, M., Ito, M. and Miyashita, Y. (1978) Diminution and reversal of eye movements induced by local stimulation of rabbit cerebellar flocculus after partial destruction of the inferior olive. Exp. Brain Res. 33, 139–141.PubMedCrossRefGoogle Scholar
  3. Dufossé, M., Ito, M., Jastreboff, P.J. and Miyashita, Y. (1978) A neuronal correlate in rabbit’s cerebellum to adaptive modification of the vestibulo-ocular reflex. Brain Res. 150, 511–616.CrossRefGoogle Scholar
  4. Eccles, J.C., Ito, M. and Szentâgothai, J. (1967) The Cerebellum as a Neuronal Machine. New York, Heidelberg: Springer.Google Scholar
  5. Ekerot, C.-F. and Oscarsson, O. (1981) Prolonged depolarization elicited in Purkinje cell dendrites by climbing fibre impulses in the cat. J. Physiol. 318, 207–221.PubMedGoogle Scholar
  6. Flourens, P. (1842) Recherches experimentales sur les propriétés et les fonctions du système nerveux dans les animaux vertébrés. Paris: Bailliere.Google Scholar
  7. Gonshor, A. and Melvill-Jones, G. (1976a) Short-term adaptive changes in the human vestibulo-ocular reflex arc. J. Physiol. 265, 361–379.Google Scholar
  8. Gonshor, A. and Melvill-Jones, G. (1976b) Extreme vestibulo-ocular adaptation induced by prolonged optical reversal of vision. J. Physiol. 256, 381–414.PubMedGoogle Scholar
  9. Hacket, J.T., Hou, S.-M. and Cochran, S.L. (1979) Glutamate and synaptic depolarization of Purkinje cells evoked by parallel fibers and by climbing fibers. Brain Res. 170, 377–380.CrossRefGoogle Scholar
  10. Haddad, G.M., Demer, J.L. and Robinson, D.A. (1980) The effect of lesions of the dorsal cap of the inferior olive on the vestibulo-ocular and optokinetic system of the cats. Brain Res. 185, 265–275.PubMedCrossRefGoogle Scholar
  11. Ito, M. (1970) Neurophysiological aspects of the cerebellar motor control system. Int. J. Neurol. 7, 162–176.PubMedGoogle Scholar
  12. Ito, M. (1972) Neural design of the cerebellar motor control system. Brain Res. 40, 81–84.PubMedCrossRefGoogle Scholar
  13. Ito, M. (1974) The control mechanisms of cerebellar motor system. In The Neurosciences, Third Study Program, ed. F.O. Schmitt, F.G. Worden, 293–303.Google Scholar
  14. Ito, M. and Miyashita, Y. (1975) The effects of chronic destruction of inferior olive upon visual modification of the horizontal vestibulo-ocular reflex of rabbits. Proc. Jpn Acad. 51, 716–760.Google Scholar
  15. Ito, M., Jastreboff, P.J. and Miyashita, Y. (1980) Retrograde influence of surgical and chemical flocculectomy upon dorsal cap neurons of the inferior olive. Neurosci. Lett. 20, 45–48.Google Scholar
  16. Ito, M., Sakurai, M. and Tongroach, P.(1981a) Evidence for modifiability of parallel fiber-Purkinje cell synapses. In Advances in Physiological Sciences 2,97105. Oxford: Pergamon.Google Scholar
  17. Ito, M., Shiida, T., Yagi, N. and Yamamoto, M. (1974) The cerebellar modification of rabbit’s horizontal vestibule-ocular reflex induced by sustained head rotation combined with visual stimulation. Proc. Jpn Acad. 50, 85–89.Google Scholar
  18. Llinâs, R. and Sugimori, M. (1980) Electrophysiological properties of in intro Purkinje cell dendrites in mammalian cerebellar slices. J. Physiol. 305, 197–213.PubMedGoogle Scholar
  19. Luciani, L. (1891) Il Cerevelletto: Nuovi Studi di Fisiologia normale e pathologica. Flourens: Le Monnier.Google Scholar
  20. Marr, D. (1969) A theory of cerebellar cortex. J. Physiol. 202, 437–470.PubMedGoogle Scholar
  21. Miledi, R. (1980) Intracellular calcium and desensitization of acetylcholine receptors. Proc. Roy. Soc. B 209, 447–452.Google Scholar
  22. Miles, F.A., Braitman, D.J. and Dow, B.M. (1980) Longterm adaptive changes in primate vestibuloocular reflex. IV. Electrophysiological observations in flocculus of adpated monkeys. J. Neurphysiol. 43, 1477–1493.Google Scholar
  23. Renaud, L.P., Blume, H.W., Pittman, Q.J., Lamour, Y. and Tan, A.T. (1979) Thyrotropin-releasing hormone selectively depressed glutamate excitation of cerebral cortical neurons. Science N.Y. 205, 1275–1277.CrossRefGoogle Scholar
  24. Robinson, D.A. (1976) Adaptive gain control of vestibule-ocular reflex by the cerebellum. J. Neurophysiol. 39, 954–969.PubMedGoogle Scholar
  25. Sandoval, M.E. and Cotman, C.W. (1978). Evaluation of glutamate as a neurotransmitter of cerebellar parallel fibers. Neurosci. 3, 199–206.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Masao Ito
    • 1
  1. 1.Department of PhysiologyFaculty of Medicine University of TokyoBunkyoku Tokyo 113Japan

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