Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins

  • David A. Jans
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

As we saw in the previous chapter, the membrane, and in particular its integral and peripheral membrane protein components, are not organized as simplistically, or at least functionally, as envisaged in the fluid mosaic model. Firstly, there is clearly a domain structure, with many physical restrictions to long range protein lateral movement within the plane of the membrane; that is, diffusion may only occur within limited areas or domains of the membrane. Secondly, many membrane proteins have reduced or essentially no mobility through a variety of specific mechanisms, such as linkage to the cytoskeleton, aggregation, etc. Accordingly, it is crucial to any critical examination of the tenets of the Mobile Receptor Hypothesis to examine the evidence for the actual mobility of plasma membrane integral receptors. This chapter will thus concentrate on lateral mobility measurements for plasma membrane integral receptors for polypeptide hormones (see refs. 1–3) and draw general conclusions with respect to receptor movement in the context of the possible relevance to signal transduction. The succeeding chapter (chapter 5) will then deal specifically with the direct and indirect evidence for a role for polypeptide hormone receptor lateral movement in signal transduction, while chapter 6 will discuss the role of receptor lateral movement in the desensitization of response subsequent to hormonal stimulation. Chapter 7 rounds the picture by concentrating on the specific role of receptor immobilization in signaling events relating particularly to immune responses and cell adhesion.

Keywords

Polypeptide Choline Thrombin Neuroblastoma Azide 

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© R.G. Landes Company 1997

Authors and Affiliations

  • David A. Jans
    • 1
  1. 1.John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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