The Cytochrome P-450-Mediated Metabolism of Biphenyl and the 4-Halobiphenyls
Recent studies of the metabolism of 4-chlorobiphenyl by rat hepatic microsomes revealed that (1) the metabolite profile is dominated by 4’-chloro-4-biphenylol and is unaltered by the induction of cytochrome P-450 by either phenobarbitone (PB)-type or 3-methylcholanthrene (MC)-type inducers and (2) the rate of 4-chlorobiphenyl metabolism is inducible by MC-type inducers whereas PB-type inducers have comparatively little or no inductive effect (Crawford and Safe, 1979; Parkinson et al., 1980; Kennedy et al., 1980).
KeywordsMetabolite Profile Water Partition Coefficient Microsomal Cytochrome Putative Binding Animal Pretreatment
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- Crawford, A., and Safe, S., 1979, 4-Chlorobiphenyl Metabolism: the effects of chemical inducers, Gen. Pharmac., 10: 227.Google Scholar
- Halpaap, K., Horning, E.C. and Horning, M.G., 1978, Comparison of the metabolism of biphenyl, 4-chlorobiphenyl and 4-fluorobiphenyl, Toxicol. Appl. Pharmacol., 45: 237.Google Scholar
- Kimaki, K., Sato, M., Kon, H. and Nebert, D.W., 1978, Correlation of Type I, Type II, and reverse Type I difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species, J. Biol. Chem., 253: 1048.Google Scholar
- Werringloer, J., Kawano, S. and Estabrook, R.W., 1979, Spin state transitions of liver microsomal cytochrome P-450, Acta Biol. Med. Germ., 38: 163.Google Scholar