The Cytochrome P-450-Mediated Metabolism of Biphenyl and the 4-Halobiphenyls

  • Andrew Parkinson
  • Stephen Safe
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Recent studies of the metabolism of 4-chlorobiphenyl by rat hepatic microsomes revealed that (1) the metabolite profile is dominated by 4’-chloro-4-biphenylol and is unaltered by the induction of cytochrome P-450 by either phenobarbitone (PB)-type or 3-methylcholanthrene (MC)-type inducers and (2) the rate of 4-chlorobiphenyl metabolism is inducible by MC-type inducers whereas PB-type inducers have comparatively little or no inductive effect (Crawford and Safe, 1979; Parkinson et al., 1980; Kennedy et al., 1980).


Metabolite Profile Water Partition Coefficient Microsomal Cytochrome Putative Binding Animal Pretreatment 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Andrew Parkinson
    • 1
  • Stephen Safe
    • 1
  1. 1.Guelph-Waterloo Centre for Graduate Work in Chemistry Department of ChemistryUniversity of Guelph GuelphOntarioCanada

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