Benzil, a Selective Inducer and a Potent in Vitro Activator of Microsomal Epoxide Hydrolase
It is now well known that many chemical carcinogens, including the polycyclic hydrocarbons, must be metabolized to reactive intermediates before they can exert their biological effectsl. It is believed that both the carcinogenicity and mutagenicity of polycyclic hydrocarbons results from the covalent binding of such intermediates to protein, RNA, and/or DNA. In the case of benzo(a)pyrene the diol epoxide 7,8-dihydro-7,8dihydroxybenzo(a)pyrene-9,10-epoxide may well be the ultimate carcinogen.
KeywordsEpoxide Hydrolase Styrene Oxide Polycyclic Hydrocarbon Selective Inducer Microsomal Epoxide Hydrolase
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