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Metabolism of Polycyclic Aromatic Hydrocarbons in Placenta

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Biological Reactive Intermediates—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 136))

Abstract

During the decade of the ′70’s it became obvious that placental tissues of several common laboratory species, non-human primates and humans were severely limited in terms of capacity to catalyze enzymatically the biotransformation and oanjugation of most foreign organic chemicals. Nevertheless, the exceptions to this generalization have proven to be quite interesting and potentially important from the viewpoint of the developing conceptus. As studies of placental drug biotransformation progressed, it was striking that many of the foreign substances that acted as substrates for placental nonooxygenase systems were promutagens and procarcinogens whose rates of oxygenation were markedly increased by preexposure to environmental inducing agents of the methylcholanthrene type. Examples of such substrates included benzo(a)pyrene (BaP) and 3’-methyl-4 monomethylaminoazobenzene (Welch, et al., 1969), N-2-fluoreriylacetamide (FAA) (Juchau, et al., 1975), 3-methylcholanthrene (3-MC) (Guibbert, et al., 1972), and 7, 12-dimethylbenz(a)anthracene (DMBA) (Juchau, et al.,1978a,b). The subject has been reviewed on numerous occasions; several recent reviews appeared within the past two years (Juchau, 1980a,b; Pelkonen, et al., 1979; Juchau, 1981a,b; Chao and Juchau, 1981).

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Authors and Affiliations

  1. Department of Pharmacology School of Medicine, University of Washington, SJ-30, Seattle, WA, 98195, USA

    M. R. Juchau, S. T. Chao & M. J. Namkung

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  1. M. R. Juchau
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  2. S. T. Chao
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  3. M. J. Namkung
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Editor information

Editors and Affiliations

  1. Rutgers University, Piscataway, New Jersey, USA

    Robert Snyder , Charlotte M. Witmer  & Beatrice N. Engelsberg ,  & 

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow  & Stephen L. Longacre  & 

  3. University of Surrey, Guildford, Surrey, England

    Dennis V. Parke  & C. Gordon Gibson  & 

  4. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    James J. Kocsis  & George F. Kalf  & 

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Juchau, M.R., Chao, S.T., Namkung, M.J. (1982). Metabolism of Polycyclic Aromatic Hydrocarbons in Placenta. In: Snyder, R., et al. Biological Reactive Intermediates—II. Advances in Experimental Medicine and Biology, vol 136. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0674-1_41

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  • DOI: https://doi.org/10.1007/978-1-4757-0674-1_41

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