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Enzymatic Hydration of Butadiene Monoxide and Its Importance in the Metabolism of Butadiene

  • E. Malvoisin
  • M. Mercier
  • M. Roberfroid
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

1,3-Butadiene is a major industrial chemical used in the production of synthetic elastomers such as polybutadiene and styrene-butadiene rubber (SBR). Like most of the unsaturated olefins, butadiene is metabolized in vivo. The first step of its biotransformation is the cytochrome P-450-dependent epoxidation to butadiene monoxide (Malvoisin et al, 1979). Both butadiene and butadiene monoxide have been shown to be mutagenic in the Ames test (de Meester et al, 1978).

Keywords

Styrene Oxide Glass Capillary Column Cyclohexene Oxide Peroxyacetic Acid Vinyl Cyclohexene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • E. Malvoisin
    • 1
  • M. Mercier
    • 1
  • M. Roberfroid
    • 1
  1. 1.Laboratory of BiotoxicologyUniversité Catholique de LouvainBrusselsBelgium

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