Covalent Binding of Metabolically Activated Hydrocarbons to Specific Microsomal Proteins
Many toxic and/or carcinogenic compounds become covalently bound to DNA, RNA, and proteins of target cells (Jollow et al., 1977). These compounds often have to be metabolised to chemically reactive forms before they can bind to macromolecules (Miller and Miller, 1972; Gillette et al., 1974). Usually this metabolic activation is catalysed by the mixed-function oxidase system located principally in the endoplasmic reticulum.
KeywordsLiver Microsome Covalent Binding Microsomal Protein Carcinogenic Compound Liver Microsomal Protein
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