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Genetics of the Complement System

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Advances in Human Genetics

Part of the book series: Advances in Human Genetics ((AHUG,volume 7))

Abstract

The classic complement system consists of nine numbered components and two or three inhibitors. The first component comprises three subcomponents, Clq, Clr, and Cls, and it is the molecular interaction between Clq and aggregated IgG or IgM (as in an antigen-antibody complex) that initiates activation of the classic complement sequence (Fig. 1).

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Authors and Affiliations

  1. Center for Blood Research Division of Immunology, Children’s Hospital Medical Center, USA

    Chester A. Alper & Fred S. Rosen

  2. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

    Chester A. Alper & Fred S. Rosen

Authors
  1. Chester A. Alper
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  2. Fred S. Rosen
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Editors and Affiliations

  1. University College London, London, England

    Harry Harris (Galton Professor of Human Genetics) (Galton Professor of Human Genetics)

  2. Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics) (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics)

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© 1976 Springer Science+Business Media New York

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Alper, C.A., Rosen, F.S. (1976). Genetics of the Complement System. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0659-8_4

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  • DOI: https://doi.org/10.1007/978-1-4757-0659-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0661-1

  • Online ISBN: 978-1-4757-0659-8

  • eBook Packages: Springer Book Archive

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