Heart Model Supported in Organ Culture and Analyzed by Acoustic Microscopy

  • Reginald C. Eggleton
  • F. Stephen Vinson


Various cardiac models have been described in the literature which have been used extensively in the study of the physiology, biochemistry and pharmacology of the heart. Since the original work of Langendorff in 18981 there have been numerous improvements in cardiac models. Bleehen and Fisher2 simplified the preparation by adding recirculation. In the original cardiac model, no ventricular filling occurred; thus little work was done by the left ventricle, i.e., work done in contraction is a function of the initial length of the fibers. To correct this deficiency, Morgan et al.3 added loading to the heart. Opie4 in England and Arnold and Lochner5 on the continent prepared an isovolumic constant volume, and later, Neely (1967)6 and Rabitzsch (1968)7 improved on the working heart model. Since that time various other improvements have been added.8–10


Organ Culture Transit Time Heart Model Acoustic Image Acoustic Microscopy 


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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Reginald C. Eggleton
    • 1
  • F. Stephen Vinson
    • 1
  1. 1.Indiana University School of Medicine, and Fortune-Fry Research Laboratories of thee Indianapolis Center for Advanced ResearchIndianapolisUSA

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