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The Physical Chemistry of Cholanic Acids

  • Donald M. Small

Abstract

The conjugated bile acids are biologically the most important detergentlike molecules (1). They solubilize the insoluble components of bile, such as lecithin and cholesterol (2–9), aid in digestion by removing the products of pancreatic hydrolysis (monoglycerides and fatty acids) (10–12), and probably control certain intracellular events such as the synthesis of cholesterol in the intestinal mucosa (13). In certain cases, secondary bile salts may be toxic to cells and may cause cholestasis and hepatic necrosis (14–26). It is the belief of this author that the physicochemical characteristics of bile salts and their molecular interactions with other lipids, proteins, and complex carbohydrate molecules probably account for not only the physiological properties of bile salts but also the pathological conditions attributed to them.

Keywords

Bile Acid Bile Salt Cholanic Acid Critical Micellar Concentration Deoxycholic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1971

Authors and Affiliations

  • Donald M. Small
    • 1
  1. 1.Section of Biophysics Department of MedicineBoston University School of MedicineUSA

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