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Experimental Ethanol Ingestion: Sleep Variables and Metabolites of Dopamine and Serotonin in the Cerebrospinal Fluid

  • Vincent Zarcone
  • Jack Barchas
  • Eric Hoddes
  • Jacques Montplaisir
  • Robert Sack
  • Richard Wilson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)

Abstract

Many previous investigators have reported the effects of ethanol on sleep. Yules, et al. (1966, 1967), Knowles and Laverty (1968), and Rundell, et al. (1972) have demonstrated that acute doses of ethanol given to normal subjects cause a decrease in rapid eye movement sleep followed by a compensatory increase, or rebound, during withdrawal. Ethanol also increases the amount of beta activity (16–18 Hz) in the sleep EEG, and causes an increase in both the heart and respiration rates. In clinical observations made on alcoholics following heavy drinking periods by Gross et al. (1966), and Greenberg and Pearlman (1967), and in experimental ethanol ingestion studies done by Johnson (1971) and Gross et al. (1971), profound effects on both rapid eye movement sleep and slow wave sleep were noted. In addition, Allen et al. (1971) have noted that REM sleep is fragmented and stage three and four sleep decreased for many weeks after abstinence began.

Keywords

Sleep Onset Total Sleep Time Slow Wave Sleep Wake Time Ingestion Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Vincent Zarcone
    • 1
    • 2
  • Jack Barchas
    • 1
  • Eric Hoddes
    • 1
  • Jacques Montplaisir
    • 1
  • Robert Sack
    • 1
  • Richard Wilson
    • 1
  1. 1.Dept. of Psychiatry and Behavioral ScienceStanford University School of MedicinePalo AltoUSA
  2. 2.Palo Alto Veterans Administration HospitalPalo AltoUSA

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