Abstract
Our working hypothesis was presented at the previous ICAA symposium on alcohol intoxication and withdrawal in Amsterdam 1972 (Wallgren, 1973). We assume that prolongation of the depressant action of alcohol causes compensatory changes particularly in those neuronal membrane structures which are involved in control of the excitation cycle of the conducting membranes. Adaptive changes in the synaptic region are presumably also involved and actually form an important focussing point for current alcohol research.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Akera, T., Rech, R.H., Marquis, W.J., Tobin, T., and Brody, T.M., 1973. Lack of relationship between brain (Nat, K+)-activated adenosine triphosphatase and the development of tolerance to ethanol in rats, J. Pharmacol. Exp. Ther. 185: 594–601.
Arvola, A., Sammalisto, L., and Wallgren, H., 1958. A test for level of alcohol intoxication in the rat, Quart. J. Stud. Alc. 19: 563–572.
Bowler, K. and Duncan, C.J., 1968. Effect of temperature on the Mgt+ dependent and Na+-K+ATPases of a rat brain microsomal preparation, Comp. Biochem. Physiol. 24: 1043–1054.
Cicero, T.J., Snider, S.R., Perez, V.J., and Swanson, L.W., 1971. Physical dependence on and tolerance to alcohol in the rat, Physiol. Behay. 6: 191–198.
Falk, J.L., Samson, H.H., and Winger, G., 1972. Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat, Science 177: 811–813.
Folch, J., Ascoli, I., Lees, M., Meath, J.A., and LeBaron, F.N., 1951. Preparation of lipide extracts from brain tissue, J. Biol. Chem. 191: 833–841.
Folch, J. and Lees, M., 1951. Proteolipides, a new type of tissue lipoproteins, J. Biol. Chem. 191: 807–817.
Goldstein, D.B., 1972. Relation of alcohol dose intensity of Withdrawal signs in mice, J. Pharmacol. Exp. Ther. 180: 203–215.
Goldstein, D.B. and Israel, Y., 1972. Effects of ethanol on mouse brain (Nat, K+)-activated adenosine triphosphatase, Life Sci. 11: Part II; 957–963.
Israel, Y., Kalant, H., LeBlanc, A.E., Bernstein, J.C., and Salazar, J., 1970. Changes in cation transport and (Na+, K+)-activated adenosine triphosphatase produced by chronic administration of ethanol, J. Pharmacol. Exp. Ther. 174: 330–336.
Israel, Y. and Kuriyama, K., 1971. Effects of in vivo ethanol administration on adenosine triphosphatase activity of sub-cellular fractions of mouse brain and liver, Life Sci. 10: 591–599.
Knox, W.H., Perrin, R.G., and Sen, A.K., 1972. Effect of chronic administration of ethanol on (Na+, K+)-activated ATPase activity in six areas of the cat brain, J. Neurochem. 19: 2881–2884.
Lieber, C.S. and De Carli, L.M., 1973. Ethanol dependence and tolerance: a nutritionally controlled experimental model in the rat, Res. Commun. Chem. Pathol. Pharmacol. 6: 983–991.
Nikander, P., 1972. Carbon electrodes for stimulation of brain tissue in vitro J. Neurochem. 19: 535–537.
Peacock, A.J., Bowler, K., and Anstee, J.H., 1972. Demonstration of a Na+-K+-Mg2+ dependent ATPase in a preparation from hindgut and Malpighian tubules of two species of insect, Experientia 28: 901–902.
Roach, M.K., Khan, M.M., Coffman, R., Pennington, W., and Davis, D.L., 1973. Brain (Na+,K+)-activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats, Brain Res. 63: 323–329.
Wallgren, H., 1973. Neurochemical aspects of tolerance to and de-pendence on ethanol, in Alcohol Intoxication and Withdrawal, Experimental Studies I, ( M.M. Gross, ed.), pp. 15–31, Plenum Press, New York.
Wallgren, H., Ahlqvist, J., Âhman, K., and Suomalainen, H., 1967. Repeated alcoholic intoxication compared with continued consumption of dilute ethanol in experiments with rats on a marginal diet, Brit. J. Nutr. 21: 643–660.
Wallgren, H. and Forsander, 0., 1963. Effect of adaptation to alcohol and of age on voluntary consumption of alcohol by rats, Brit.J. Nutr. 17: 453–457.
Wallgren, H., Kosunen, A.-L., and Ahtee, L., 1972. Technique for producing an alcohol withdrawal syndrome in rats, Brain Res. 42: 550.
Wallgren, H., Kosunen, A.-L., and Ahtee, L., 1973. Technique for producing an alcohol withdrawal syndrome in rats, Isr. J. Med. Sci. 9: Suppl. 63–71.
Wallgren, H., Nikander, P., von Boguslawsky, P., and Linkola, J., 1974. Effects of ethanol, tert.butanol and clomethiazole on net movements of sodium and potassium in electrically stimulated cerebral tissue, Acta Physiol. Scand. 91: 83–93.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wallgren, H., Nikander, P., Virtanen, P. (1975). Ethanol-Induced Changes in Cation-Stimulated Adenosine Triphospha-Tase Activity and Lipid-Proteolipid Labeling of Brain Microsomes. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal. Advances in Experimental Medicine and Biology, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0632-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0632-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0634-5
Online ISBN: 978-1-4757-0632-1
eBook Packages: Springer Book Archive