Ethanol Consumption Subsequent to Physical Dependence
A number of elegant techniques have been developed to induce pharmacological dependence on alcohol in animals. However, our understanding of the behavioral aspects of alcohol ingestion or self-administration is still quite limited. It is only quite recently that the relationship between physical dependence and subsequent alcohol intake has been investigated. Unfortunately, the few findings obtained by different investigators appear to be quite contradictory. An early study by Freund (1969) concluded that mice do not change their preference for ethanol subsequent to physical dependence. A study by Myers, Stoltman and Martin (1972) dealt with the effects of ethanol dependence induced artificially in the Rhesus monkey on the subsequent preference for alcohol. Their findings show that each monkey rejected the ethanol solution offered even at low concentrations, in spite of the fact that symptoms of physical dependence on alcohol were quite manifest. In a more recent experiment, Deutsch and Koopmans (1973) demonstrated a large and lasting enhancement of alcohol consumption over control levels after direct infusion of 10% alcohol into the stomach of rats for six days.
KeywordsWithdrawal Symptom Ethanol Consumption Physical Dependence Stepwise Fashion Alcohol Preference
Unable to display preview. Download preview PDF.