Advertisement

Establishment of Ethanol as a Reinforcer for Rhesus Monkeys Via the Oral Route: Initial Results

  • Richard A. Meisch
  • Jack E. Henningfield
  • Travis Thompson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)

Abstract

Ethanol functions as a reinforcer for rhesus monkeys when it is self-administered intravenously (Deneau, Yanagita and Seevers, 1969; Winger and Woods, 1973; Woods, Ikomi and Winger, 1971) or intragastricly (Yanagita and Takahashi, 1973). However, it has been reported that ethanol is not drunk by rhesus monkeys in either large quantities or at high concentrations except under special circumstances. For example, if rhesus monkeys are totally restricted to a liquid diet containing ethanol, physiological dependence develops (Pieper and Skeen, 1972). In three of four rhesus monkeys the chronic intraventricular infusion of ethanol resulted in abrupt and intermittent increases in ethanol intake (Myers, Veale and Yaksh, 1972), but such increases were not found in another study (Koz and Mendelson, 1967). Following a six-day interruption in the monkeys’ continuous access to ethanol, reintroduction of access to ethanol resulted in a pronounced but transient increase in intake (Sinclair, 1971).

Keywords

Rhesus Monkey Aversive Taste Ethanol Intake Food Stimulus Liquid Reinforcement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deneau, G., Yanagita, T. and Seevers, M.H. Self-administration of psychoactive substances by the monkey. A measure of psychological dependence. Psychopharmacologia, 16: 30–48, 1969.CrossRefGoogle Scholar
  2. Koz, G. and Mendelson, J.H. Effects of intraventricular ethanol infusion on free choice alcohol consumption by monkeys. In (Ed.) R.P. Maickel, Biochemical Factors in Alcoholism, New York: Pergamon, pp. 17–24, 1967.Google Scholar
  3. Meisch, R.A. and Thompson, T. Ethanol intake in the absence of concurrent food reinforcement. Psychopharmacologia, 22: 72–79, 1971.CrossRefGoogle Scholar
  4. Meisch, R.A. and Thompson, T. Ethanol reinforcement: Effects of concentration during food deprivation. International Symposium Biological Aspects of Alcohol Consumption, 27–29 September 1971, Helsinki. The Finnish Foundation for Alcohol Studies, 20: 71–75, 1972a.Google Scholar
  5. Meisch, R.A. and Thompson, T. Ethanol intake during schedule-induced polydipsia. Physiol. Behay., 8: 471–475, 1972b.CrossRefGoogle Scholar
  6. Meisch, R.A. and Thompson, T. Ethanol as a reinforcer: Effects of fixed-ratio size and food deprivation. Psychopharmacologia, 28: 171–183, 1973.CrossRefGoogle Scholar
  7. Meisch, R.A. and Thompson, T. Rapid establishment of ethanol as a reinforcer for rats. Psychopharmacologia, 1974a, in press.Google Scholar
  8. Meisch, R.A. and Thompson, T. Ethanol intake as a function of concentration during food deprivation and satiation. Pharmac. Biochem. Behay., 1974b, in press.Google Scholar
  9. Mello, N.K. and Mendelson, J.H. The effects of drinking to avoid shock on alcohol intake in primates. In (Eds.) M.K. Roach, W.M. Mclsaac and P.J. Creaven, Biological Aspects of Alcohol, Austin: University of Texas Press, pp. 313–332, 1971a.Google Scholar
  10. Mello, N.K. and Mendelson, J.H. Evaluation of a polydipsia technique to induce alcohol consumption in monkeys. Physiol. Behay., 7: 827–836, 1971b.CrossRefGoogle Scholar
  11. Myers, R. D., Stoltman, W.P. and Martin, G.E. Effects of ethanol dependence induced artifically in the rhesus monkey on the subsequent preference for ethyl alcohol. Physiol. Behay., 9: 43–48, 1972.CrossRefGoogle Scholar
  12. Myers, R. D., Veale, W.L. and Yaksh, T.L. Preference for ethanol in the rhesus monkey following chronic infusion of ethanol into the cerebral ventricles. Physiol. Behay., 8: 431–435, 1972.CrossRefGoogle Scholar
  13. Pieper, W. A. and Skeen, M.J. Induction of physical dependence on ethanol in rhesus monkeys using an oral acceptance technique. Life Sci., 11: 989–997, 1972.CrossRefGoogle Scholar
  14. Schuster, C. R. and Woods, J.H. Schedule-induced polydipsia in the rhesus monkey. Psychol. Rep., 19: 823–828, 1966.CrossRefGoogle Scholar
  15. Sinclair, J. D. The alcohol-deprivation effect in monkeys. Psychon. Sci., 25: 21–22, 1971.CrossRefGoogle Scholar
  16. Thompson, T., Schuster, C.R., Dockens, W. and Lee, R. Mouth-operated food and water manipulanda for use with monkeys J. exp. Anal. Behay., 7: 171–172, 1964.CrossRefGoogle Scholar
  17. Winger, G.D. and Woods, J.H. The reinforcing property of ethanol in the rhesus monkey: I. I.itiation, maintenance and termination of intravenous ethanol-reinforced responding. Ann. N. Y. Acad. Sci., 215: 162–175, 1973.CrossRefGoogle Scholar
  18. Woods, J.H., Ikomi, F. and Winger, G.D. The reinforcing property of ethanol. In (Eds.) M.K. Roach, W.M. Mclsaac and P.J. Creaven, Biological Aspects of Alcohol, Austin: University of Texas Press, pp. 371–388, 1971.Google Scholar
  19. Yanagita, T. and Takahashi, S. Dependence liability of several sedative-hypnotic agents evaluated in monkeys. J. Pharmac. exp. Ther., 185: 307–316, 1973.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Richard A. Meisch
    • 1
  • Jack E. Henningfield
    • 1
  • Travis Thompson
    • 1
  1. 1.Psychiatry Research UnitUniversity of MinnesotaMinneapolisUSA

Personalised recommendations