Alteration of Ethanol Preference in Rats; Effects of β-Carbolines
Our interest in the β-carbolines as influencing factors in alcohol preference stems from the early work of Mclsaac (1961) who reported the in vitro formation of 6-methoxytetrahydroharman as a condensation product of 5-methoxytryptamine and acetaldehyde. When rats were administered these agents in conjunction with their respective metabolic inhibitors, iproniazed and disulfiram, small amounts of 6-methoxytetrahydroharman were found in the urine. These findings were recently confirmed by Dajani and Sehab (1973). They reported the isolation of labelled ß-carbolines in 24 hour urine samples of rats administered labelled ethanol and 5-hydroxytryptophan or 5-methoxytryptophan.
KeywordsAlcohol Intake Monoamine Oxidase Ethanol Intake Brain Serotonin York Acad
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- Dajani, R. M. and Saheb, S. E. “A Further Insight into the Metabo- lism of Certain 3-Carbolines.” Annals New York Acad. Sci. 215: 120, 1973.Google Scholar
- Geller, I., Purdy, R., and Merritt, J. “Alterations in Ethanol Preference in the Rat: The Role of Brain Biogenic Amines.” Annals New York Acad. Sci. 215: 54, 1973.Google Scholar
- Ho. B. T., Mclsaac, W. M. and Tansey, L. W. “Inhibitors of Monoamine Oxidase IV: 6 (or 8) Substituted Tetrahydro-8-carbolines and Their 9-Methyl Analogues.” J. Pharmac. Sci. 58: 998–1001, 1969.Google Scholar