Abstract
Our interest in the β-carbolines as influencing factors in alcohol preference stems from the early work of Mclsaac (1961) who reported the in vitro formation of 6-methoxytetrahydroharman as a condensation product of 5-methoxytryptamine and acetaldehyde. When rats were administered these agents in conjunction with their respective metabolic inhibitors, iproniazed and disulfiram, small amounts of 6-methoxytetrahydroharman were found in the urine. These findings were recently confirmed by Dajani and Sehab (1973). They reported the isolation of labelled ß-carbolines in 24 hour urine samples of rats administered labelled ethanol and 5-hydroxytryptophan or 5-methoxytryptophan.
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References
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Geller, I., Purdy, R. (1975). Alteration of Ethanol Preference in Rats; Effects of β-Carbolines. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal. Advances in Experimental Medicine and Biology, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0632-1_20
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DOI: https://doi.org/10.1007/978-1-4757-0632-1_20
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