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Alteration of Ethanol Preference in Rats; Effects of β-Carbolines

  • Irving Geller
  • Robert Purdy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)

Abstract

Our interest in the β-carbolines as influencing factors in alcohol preference stems from the early work of Mclsaac (1961) who reported the in vitro formation of 6-methoxytetrahydroharman as a condensation product of 5-methoxytryptamine and acetaldehyde. When rats were administered these agents in conjunction with their respective metabolic inhibitors, iproniazed and disulfiram, small amounts of 6-methoxytetrahydroharman were found in the urine. These findings were recently confirmed by Dajani and Sehab (1973). They reported the isolation of labelled ß-carbolines in 24 hour urine samples of rats administered labelled ethanol and 5-hydroxytryptophan or 5-methoxytryptophan.

Keywords

Alcohol Intake Monoamine Oxidase Ethanol Intake Brain Serotonin York Acad 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Irving Geller
    • 1
  • Robert Purdy
    • 1
  1. 1.Southwest Foundation for Research and EducationSan AntonioUSA

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