Variations in the Acetaldehyde Level of Some Tissues in Hyper- and Hypothyroid Rats

  • Olof A. Forsander
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


Since small amounts of ethanol are always present in the blood (Krebs and Perkins 1970), minute concentrations of acetaldehyde might also be expected to be present. Large amounts, however, can only be found after alcohol consumption. Ethanol is oxidized almost exclusively in the liver, consequently the acetaldehyde in the blood must originate from this tissue.


Ethanol Oxidation Acetaldehyde Level Acetaldehyde Content Ethanol Metabolism Liver Cytosol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bäcklin, K.-J., 1958. The equilibrium constant of the system ethanol, aldehyde, DPW“, DPNH and H+, Acta Chem. Scand. 12: 1279–1285.CrossRefGoogle Scholar
  2. Deitrich, R.A., 1966. Tissue and subcellular distribution of mammalian aldehyde oxidizing capacity, Biochem. Pharmacol. 15: 1911–1922.CrossRefGoogle Scholar
  3. Depocas, F. and Hart, J.S., 1957. Use of the Pauling oxygen analyzer for measurement of oxygen consumption of animals in open-circuit systems and in short-lag, closed circuit apparatus, J. Appl. Physiol. 10: 388–392.Google Scholar
  4. Eriksson, C.J.P., 1973. Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference, Biochem. Pharmacol. 22: 2283–2292.CrossRefGoogle Scholar
  5. Fellenius, E., 1973. The interaction between ethanol and lipid metabolism in the rat liver. Thesis, Uppsala University.Google Scholar
  6. Forsander, O.A., Hillbom, M.E. and Lindros, K.O., 1969. Influence of thyroid function on the acetaldehyde level of blood and liver of intact rats during ethanol metabolism. Acta Pharmacol. Toxicol. 27 :410–416.Google Scholar
  7. Freund, G. and O’Hollaren, P., 1965. Acetaldehyde concentrations in alveolar air following a standard dose of ethanol in man, J. Lipid Res. 6: 471–477.Google Scholar
  8. Hald, J., Jacobsen, E., and Larsen, V., 1949. Formation of acetaldehyde in the organism in relation to dosage of Antabus and to alcohol-concentration in blood, Acta Pharmacol. 5: 179–188.CrossRefGoogle Scholar
  9. Hohorst, H.J., Kreutz, F.H.,and Bücher, Th., 1959. Uber Metabolitgehälte und Metabolit-Konzentrationen in der Leber der Ratte, Biochem. Z. 332: 18–46.Google Scholar
  10. Kesäniemi, Y.A., 1974a. Ethanol and acetaldehyde in the milk and peripheral blood of lactating women after ethanol administration, Brit. Common. 81: 84–86.Google Scholar
  11. Kesäniemi, Y.A., 1974b. In vivo contents of ethanol and acetaldehyde in the rat fetus during maternal ethanol oxidation, to be published.Google Scholar
  12. Kesäniemi, Y.A., 1974c. Metabolism of ethanol and acetaldehyde in intact rats during pregnancy, Biochem. Pharmacol. 23: 1157–1162.CrossRefGoogle Scholar
  13. Krebs, H.A., 1969. Role of equilibria in the regulation of metabolism, Curr. Top. Cell. Regul. 1: 45–55.Google Scholar
  14. Krebs, H.A. and Perkins, J.R., 1970. The physiological role of liver alcohol dehydrogenase. Biochem. J. 118: 635–644.Google Scholar
  15. Lahti, R.A. and Majchrowicz, E., 1967. The effects of acetaldehyde on serotonin metabolism, Life Sci. 6: 1399–1406.Google Scholar
  16. Lindros, K.O., Vihma, R., and Forsander, O.A., 1972. Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver, Biochem. J. 126: 945–952.Google Scholar
  17. Lundquist, F. and Wolthers, H., 1958. The kinetics of alcohol elimination in man, Acta Pharmacol. Toxicol. 14: 265–289.CrossRefGoogle Scholar
  18. Rawat, A.K. and Lundquist, F., 1968. Influence of thyroxine on the metabolism of ethanol and glycerol in rat liver slices, Eur. J. Biochem. 5: 13–17.CrossRefGoogle Scholar
  19. Scholz, R., 1968. Untersuchungen zur Redoxkompartmentierung bei der hämoglobinfrei perfundierten Rattenleber, in Stoffwechsel der isoliert perfundierten Leber. ( W. Steib und R. Scholz, eds.) pp. 25–147, Springer Verlag, Berlin.CrossRefGoogle Scholar
  20. Schneider, F.H., 1971. Acetaldehyde-induced catecholamine secretion from the cow adrenal medulla, J. Pharmacol. Exp. Ther. 177: 109–118.Google Scholar
  21. Sheppard, J.R., Albersheim, P., and McClearn, G., 1970. Aldehyde dehydrogenase and ethanol preference in mice, J. Biol. Chem. 245: 2876–2882.Google Scholar
  22. Sippel, H.W., 1972. Thiourea an effective inhibitor of the nonenzymatic ethanol oxidation in biological extracts, Acta Chem. Scand. 26: 3398–3400.CrossRefGoogle Scholar
  23. Sippel, H.W., 1973. Non-enzymatic ethanol oxidation in biological extracts, Acta Chem. Scand. 27: 541–550.CrossRefGoogle Scholar
  24. Sippel, H.W., 1974. The acetaldehyde content in rat brain ethanol metabolism, Biochem. Pharmacol., in press.Google Scholar
  25. Theorell, H. and Bonnichsen, R., 1951. Studies on liver alcohol dehydrogenase, Acta Chem. Scand. 5: 1105–1126.CrossRefGoogle Scholar
  26. Tottmar, O., 1974. Aldehyde dehydrogenase in rat liver. Thesis, Uppsala University.Google Scholar
  27. Truitt, E.B. and Walsh, M.J., 1971. The role of acetaldehyde in the actions of ethanol, in The Biology of Alcoholism, Vol. 1 ( B. Kissin and H. Begleiter, eds.) pp. 161–195, Plenum Press, New York.CrossRefGoogle Scholar
  28. Williamson, D.H., Lund, P., and Krebs, H.A., 1967. The redox state of the freenicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver, Biochem. J. 103: 514–527.Google Scholar
  29. Ylikahri, R.H., Mäenpää, P.H., and Hassinen, J.E., 1968. Ethanol-induced changes of cytoplasmic redox state as modified by thyroxine treatment, Ann. Med. Exp. Biol. Fenn. 46: 137–142.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Olof A. Forsander
    • 1
  1. 1.Research Laboratories of the State Alcohol Monopoly (Alko)Helsinki 10Finland

Personalised recommendations