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Chronic Granulomatous Disease

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Advances in Human Genetics

Part of the book series: Advances in Human Genetics ((AHUG,volume 16))

Abstract

Chronic granulomatous disease (CGD) is a rare inherited disorder of host defense in which the phagocytic components of the immune system (neutrophils, eosinophils, monocytes, and macrophages) fail to generate hydrogen peroxide and oxygen radicals upon stimulation. Since these oxidants are normally used by phagocytes to kill microorganisms, phagocytes from patients with CGD show impaired microbicidal activity, and the patients themselves suffer from recurrent, and often life-threatening, bacterial and fungal infections.

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  1. John T. Curnutte

    Present address: Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

Authors and Affiliations

  1. Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, Michigan, 48109, USA

    John T. Curnutte

  2. Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Bernard M. Babior

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  1. University of Pennsylvania, Philadelphia, USA

    Harry Harris (Harnwell Professor of Human Genetics) (Harnwell Professor of Human Genetics)

  2. Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Herbert H. Lehman Professor and Chairman of Pediatrics) (Herbert H. Lehman Professor and Chairman of Pediatrics)

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Curnutte, J.T., Babior, B.M. (1987). Chronic Granulomatous Disease. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0620-8_4

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