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Chemical and Cellular Architecture pp 181–188Cite as

Neuropeptides

An Overview

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Abstract

In the four decades that have passed since Ernst and Berta Scharrer suggested that certain populations of central neurons secrete peptide hormones,1 a multitude of biologically active peptides have been discovered and/or characterized in brain extracts (Table I). Some of these were first found in the brain, others in nonnervous tissue such as gut, pancreas, skin, or pituitary. When a peptide is discovered in the CNS that is present in other organs, it must be characterized. The form of the peptide in brain may be different from the form in the periphery. Furthermore, it is unsafe to assume that all peptides found in brain are made there; they may be made in the periphery and transported to and concentrated in the brain.

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Author information

Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    M. J. Brownstein

  2. Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland, 20205, USA

    H. Gainer

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  1. M. J. Brownstein
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  2. H. Gainer
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Editors and Affiliations

  1. Center for Neurochemistry, Ward’s Isalnd, New York, USA

    Abel Lajtha

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Brownstein, M.J., Gainer, H. (1982). Neuropeptides. In: Lajtha, A. (eds) Chemical and Cellular Architecture. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0614-7_7

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