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Ammonia

  • Chapter
Chemical and Cellular Architecture

Abstract

Since the early demonstrations of the harmful effects of ammonia* on man and animals1–3 and of the liberation of ammonia by stimulated nerve tissue,4 a large literature concerned with the processes (operating both in vivo and in vitro) that are involved in the neural formation, transport, utilization, function, and toxicity of ammonia has accumulated. It indicates the dynamic nature of ammonia in the brain, its direct relationship to metabolism of glucose, amino acids, and proteins, its effects on cell energetics, its significant response to physiological change, its covert involvement in transmitter function, its influence on membrane properties and on cell morphology, and its implication at hyperconcentrations in convulsions and coma. Some of these aspects have been reviewed in the last two decades.3,5–14 In this chapter, an attempt will be made at collation and synthesis of some of the early and present knowledge of the field.

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  1. Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia, V6T lW5, Canada

    A. M. Benjamin

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  1. Center for Neurochemistry, Ward’s Isalnd, New York, USA

    Abel Lajtha

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Benjamin, A.M. (1982). Ammonia. In: Lajtha, A. (eds) Chemical and Cellular Architecture. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0614-7_4

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