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Abstract

During the decade since the first appearance of this Handbook, few, if any, major areas of neurobiology have developed at a faster rate than our knowledge of astrocytic biochemistry and function. This development is undoubtedly related to the methodologies that became available during the 1960s and early 1970s, i.e., microdissection of samples consisting primarily of glial cells,1 bulk separation by gradient centrifugation of a fraction highly enriched in astroglia,2–6 and culturing of glial cells either in cell lines, e.g., the C-6 glioma cell line,7 or in primary cultures of astrocytes.8,9 Each of these methodologies has its own sources of error and uncertainties.6,10–13 These include cross contamination between isolated cell fractions, dedifferentiation of transformed cell lines, and the possibility of a deficient maturation in primary cultures that are prepared from biochemically immature tissue. These factors may not only delete or reduce astrocytic characteristics from the astrocytic preparations but may also add nonastrocytic qualities. In this connection, it should be kept in mind that neurons, astrocytes, and oligodendrocytes develop from common precursor cells (subventricular cells), meaning that cells that remain at, or revert to, immature stages may display phenomena that, in the adult brain, are only displayed by the other cell types. Because of these potential sources of error, great caution should be exerted before any particular characteristic is accepted as astrocytic, although features that have been established using different preparations of astrocytes are likely to represent true characteristics of astrocytes.

Keywords

Glial Cell Glioma Cell Primary Culture ATPase Activity Oxygen Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • L. Hertz
    • 1
  1. 1.Department of PharmacologyUniversity of SaskatchewanSaskatoonCanada

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