The Role of Papillomaviruses in Human Anogenital Cancer

  • Harald zur Hausen
  • Achim Schneider
Part of the The Viruses book series (VIRS)

Abstract

Since 1842 (Rigoni-Stern), numerous epidemiological studies point to an infectious event in the etiology of human cervical cancer (reviewed by: Rotkin, 1973; Kessler, 1977; zur Hausen, 1977). Venereal transmission of a carcinogenic factor with a long latency period has been postulated in many of these studies. Sexual promiscuity, early onset of sexual activity, and poor hygienic conditions appear to be the prime risk factors for cervical cancer.

Keywords

Codon Adenocarcinoma Nicotine Oncol Smoke 

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References

  1. Amtmann, E., Müller, H., and Sauer, G., 1980, Equine connective tissue tumors contain unintegrated bovine papilloma virus DNA, J. Virol. 35: 962–964.PubMedGoogle Scholar
  2. Auersperg, N., 1964, Long-term cultivation of hypodiploid human tumor cells, J. Natl. Cancer Inst. 32: 135–163.PubMedGoogle Scholar
  3. Beckmann, A. M., Daling, J. R., and McDougall, J. K., 1985, Human papillomavirus DNA in anogenital carcinomas, J. Cell Biochem. Suppl. 9c: 68.Google Scholar
  4. Boshart, M., and zur Hausen, H., 1986, Human papillomavirus (HPV) in Buschke-Lowenstein tumors: Physical state of the DNA and identification of a tandem duplication in the non-coding region of a HPV-6 subtype, J. Virol. 58: 963–966.PubMedGoogle Scholar
  5. Boshart, M., Gissmann, L., Ikenberg, H., Kleinheinz, A., Scheurlen, W., and zur Hausen, H., 1984, A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer, EMBO J. 3: 1151–1157.PubMedGoogle Scholar
  6. Buschke, A., and Löwenstein, L., 1931, Über carcinomähnliche Condylomata acuminata des Penis, Arch. Dermatol. Syph. 163: 30–46.Google Scholar
  7. Cartwright, R. A., and Sinson, J. D., 1980, Carcinoma of penis and cervix, Lancet 1: 97.Google Scholar
  8. Chen, E. Y., Howley, P. M., Levinson, A. D., and Seeburg, P. H., 1982, The primary structure and genetic organization of the bovine papillomavirus type 1 genome, Nature 299: 529–534.PubMedCrossRefGoogle Scholar
  9. Clarke, E. A., Morgan, R. W., and Newman, A. M., 1982, Smoking as a risk factor in cancer of the cervix: Additional evidence from a case control study, Am. J. Epidemiol. 115: 59–66.PubMedGoogle Scholar
  10. Coggin, J. R., and zur Hausen, H., 1979, Workshop on papillomaviruses and cancer, Cancer Res. 39: 545–546.Google Scholar
  11. Crum, C. P., Nagai, N., Mitao, M., Levine, R. U., and Silverstein, S. J., 1985, Histological and molecular analysis of early cervical neoplasia, J. Cell Biochem. Suppl. 9c: 70.Google Scholar
  12. Danos, O., Katinka, M., and Yaniv, M., 1982, Human papillomavirus la complete DNA sequence: A novel type of genome organization among papovaviridae, EMBO J. 1: 231–236.PubMedGoogle Scholar
  13. Dartmann, K., Schwarz, E., Gissmann, L., and zur Hausen, H., 1986, The nucleotide sequence and genome organization of human papilloma virus type 11, Virology 151: 124–130.PubMedCrossRefGoogle Scholar
  14. deLap, R., Friedman-Kien, A., and Rush, M. G., 1976, The absence of human papilloma viral sequences in condylomata acuminata, Virology 74: 268–272.PubMedCrossRefGoogle Scholar
  15. Della Torre, G., Pilotti, S., de Palo, G., and Rilke, F., 1978, Viral particles in cervical condylomatous lesions, Tumori 64: 456–463.Google Scholar
  16. de Villiers, E.-M., Gissmann, L., and zur Hausen, H., 1981, Molecular cloning of viral DNA from human genital warts, J. Virol. 40: 932–935.PubMedGoogle Scholar
  17. de Villiers, E.-M., Schneider, A., Gross, G., and zur Hausen, H., 1986, Analysis of benign and malignant urogenital tumors for human papillomavirus infection by labeling cellular DNA, Med. Microbiol. Immunol. 174: 281–286.PubMedCrossRefGoogle Scholar
  18. Duff, R., and Rapp, F., 1973, Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1, J. Virol. 12: 209–217.PubMedGoogle Scholar
  19. Durst, M., Gissmann, L., Ikenberg, H., and zur Hausen, H., 1983, A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions, Proc. Natl. Acad. Sci. USA 80: 3812–3815.PubMedCrossRefGoogle Scholar
  20. Durst, M., Kleinheinz, A., Hotz, M., and Gissmann, L., 1985, The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors, J. Gen. Virol. 66: 1515–1522.PubMedCrossRefGoogle Scholar
  21. Freedman, R. S., Bowen, J. M., Leibovitz, A., Pethak, S., Siciliano, M. J., Gallagher, H. S., and Giovanella, B. C., 1982, Characterization of a cell line (SW 756) derived from a human squamous carcinoma of the uterine cervix, In Vitro 18: 719–726.PubMedCrossRefGoogle Scholar
  22. Frenkel, N., Roizman, B., Cassai, E., and Nahmias, A., 1972, A DNA fragment of herpes simplex 2 and its transcription in human cervical cancer tissue, Proc. Natl. Acad. Sci. USA 69: 3784–3789.PubMedCrossRefGoogle Scholar
  23. Friedl, F., Kimura, I., and Osato, T., 1979, Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology, Proc. Soc. Exp. Biol. Med. 135: 543–545.Google Scholar
  24. Fu, Y. S., Reagan, J. W., and Richart, R. M., 1981, Definition of precursors, Gynecol. Oncol. 12: 220–231.CrossRefGoogle Scholar
  25. Galloway, D. A., and McDougall, J. K., 1983, The oncogenic potential of herpes simplex viruses: Evidence for a “hit-and-run” mechanism, Nature 302: 21–24.PubMedCrossRefGoogle Scholar
  26. Gey, G. O., Coffman, W. D., and Kubicek, M. T., 1952, Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium, Cancer Res. 12: 264–265.Google Scholar
  27. Gissmann, L., and zur Hausen, H., 1980, Partial characterization of viral DNA from human genital warts (condylomata acuminata), Int. J. Cancer 25: 605–609.PubMedCrossRefGoogle Scholar
  28. Gissmann, L., Diehl, V., Schultz-Coulon, H.-J., and zur Hausen, H., 1982, Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma, J. Virol. 44: 393–400.PubMedGoogle Scholar
  29. Gissmann, L., Wolnik, L., Ikenberg, H., Koldovsky, U., Schnürch, H. G., and zur Hausen, H., 1983, Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers, Proc. Natl. Acad. Sci. USA 80: 560–563.PubMedCrossRefGoogle Scholar
  30. Graham, S., Priore, R., Graham, M., Browne, R., Burnett, W., and West, D., 1979, Genital cancer in wives of penile cancer patients, Cancer 44: 1870–1974.PubMedCrossRefGoogle Scholar
  31. Green, M., Brackmann, K. H., Sanders, P. R., Loewenstein, P. M., Fred, J. H., Eisinger, M., and Switlyk, S. A., 1982, Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: Presence of related viral DNA in human urogenital tumors, Proc. Natl. Acad. Sci. USA 79: 4437–4441.PubMedCrossRefGoogle Scholar
  32. Gross, L., 1983, Oncogenic Viruses, Pergamon Press, Elmsford, N.Y.Google Scholar
  33. Heilbronn, R., Schlehofer, J. R., and zur Hausen, H., 1984, Selective killing of carcinogen-treated SV-transformed Chinese hamster cells by a defective parvovirus, Virology 136. 439–441.PubMedCrossRefGoogle Scholar
  34. Heilbronn, R., Schlehofer, J. R., Yalkinoglu, A. O., and zur Hausen, H., 1985, Selective DNA-amplification induced by carcinogens (initiators): Evidence for a role of proteases and DNA polymerase alpha, Int. J. Cancer 36: 85–91.PubMedCrossRefGoogle Scholar
  35. Heilman, C. A., Law, M.-F., Israel, M. A., and Howley, P. M., 1980, Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequence, J. Virol. 36: 395–407.PubMedGoogle Scholar
  36. Hoffmann, D., Hecht, S. S., Haley, N. J., Brunnemann, K. D., Adams, J. D., and Wynder, E. L., 1985, Turmorigenic agents in tobacco products and their uptake by chewers, smokers and nonsmokers, J. Cell Biochem. Suppl. 9C: 33.Google Scholar
  37. Ikenberg, H., Gissmann, L., Gross, G., Grussendorf, E.-I., and zur Hausen, H., 1983, Human papillomavirus type 16-related DNA in genital Bowen’s disease and in Bowenoid papulosis, Int. J. Cancer 32: 563–565.PubMedCrossRefGoogle Scholar
  38. Jagella, H. P., and Stegner, H. E., 1974, Zur Dignität der Condylomata acuminata: Klinische, histopathologische und cytophotometrische Befunde, Arch. Gynaekol. 216: 119–132.CrossRefGoogle Scholar
  39. Jenson, A. B., Rosenthal, J. D., Olson, C., Pass, F., Lancaster, W. D., and Shah, K., 1980, Immunologic relatedness of papillomaviruses from different species, J. Natl. Cancer Res. 64: 495–500.Google Scholar
  40. Kahn, T., Schwarz, E., and zur Hausen, H., 1986, Molecular cloning and characterization of the DNA of a new human papillomavirus (HPV 30) from a laryngeal carcinoma, Int. J. Cancer 37: 61–65.PubMedCrossRefGoogle Scholar
  41. Kessler, I., 1977, Venereal factors in human cervical cancer: Evidence from marital clusters, Cancer 39: 1912–1919.PubMedCrossRefGoogle Scholar
  42. Koss, L. G., and Durfee, G. R., 1956, Unusual patterns of squamous epithelium of the uterine cervix: Cytologic and pathologic study of koilocytotic atypia, Ann. N.Y. Acad. Sci. 63: 1245–1261.PubMedCrossRefGoogle Scholar
  43. Laverty, C. R., Russel, P., Hills, E., and Booth, N., 1978, The significance of the noncondylomatous wart virus infection of the cervical transformation zone: A review with discussion of two illustrative cases, Acta Cytol. 22: 195–201.PubMedGoogle Scholar
  44. Lorincz, A. T., Lancaster, W. D., and Temple, G. F., 1985, Detection and characterization of a new type of human papilloma virus, J. Cell Biochem. Suppl. 9c: 75.Google Scholar
  45. MacMahon, B., and Sugimura, T. (eds.), 1984, Coffee and Health, Banbury Report 17, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  46. Maggregor, J. E., and Innes, G., 1980, Carcinoma of penis and cervix, Lancet 1: 1246–1247.Google Scholar
  47. Maitland, N. J., Kinross, J. H., Buttusil, A., Ludgate, S. M., Smart, G. E., and Jones, K. W., 1981, The detection of DNA tumour virus-specific RNA sequences in abnormal human cervical biopsies by in situ hybridization, J. Gen. Virol. 55: 123–137.PubMedCrossRefGoogle Scholar
  48. Martinez, J., 1969, Relationship of squamous cell carcinoma of the cervix uteri to squamous cell carcinoma of the penis, Cancer 24: 777–780.PubMedCrossRefGoogle Scholar
  49. Matz, B., Schlehofer, J. R., and zur Hausen, H., 1984, Identification of a gene function of herpes simplex virus type 1 essential for amplification of simian virus 40 DNA sequences in transformed hamster cells, Virology 134: 328–337.PubMedCrossRefGoogle Scholar
  50. Meisels, A., and Fortin, R., 1976, Condylomatous lesions of the cervix and vagina. I. Cytologic patterns, Acta Cytol. 20: 505–509.PubMedGoogle Scholar
  51. Meisels, A., Fortin, R., and Roy, M., 1977, Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study, Acta Cytol. 21: 379–390.PubMedGoogle Scholar
  52. Meisels, A., Roy, M., Fortier, M., Morin, C., Casas-Cordero, M., Shah, K. V., and Turgeon, H., 1981, Human papilloma virus infection of the cervix: The atypical condyloma, Acta Cytol. 25: 7–16.PubMedGoogle Scholar
  53. Mounts, P., Shah, K. V., and Kashima, H., 1982, Viral etiology of juvenile-and adult onset squamous papilloma of the larynx, Proc. Natl. Acad. Sci. USA 79: 5425–5429.PubMedCrossRefGoogle Scholar
  54. Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C. F., and Guest, B. A., 1969, Antibodies to herpes virus hominis types 1 and 2 in humans. II. Women with cervical cancer, Am. J. Epidemiol. 91: 547–552.Google Scholar
  55. Oriel, J. D., 1971, Anal warts and anal coitus, Br. J. Vener. Dis. 47: 373–376.PubMedGoogle Scholar
  56. Orth, G., Favre, N., Jablonska, S., Brylak, K., and Croissant, O., 1978, Viral sequences related to a human skin papilloma virus in genital warts, Nature 275: 334–336.PubMedCrossRefGoogle Scholar
  57. Orth, G., Favre, M., Breitburd, F., Croissant, O., Jablonska, S., Obalek, S., Jarzabek-Chorzelska, M., and Rzesa, G., 1980, Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer, in: Viruses in Naturally Occurring Cancers ( M. Essex, G. Todaro, and H. zur Hausen, eds.), pp. 259–282, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  58. Ostrow, R. S., Bender, M., Niimura, M., Seki, T., Kawashima, M., Pass, F., and Faras, A. J., 1982, Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis, Proc. Natl. Acad. Sci. USA 79: 1634–1638.PubMedCrossRefGoogle Scholar
  59. Park, M., Kitchener, H. C., and Macnab, J. C. M., 1983, Detection of herpes simplex virus type 2 DNA restriction fragments in human cervical carcinoma tissue, EMBO J. 2: 1029–1034.PubMedGoogle Scholar
  60. Pattillo, R. A., 1977, Tumor antigen and human gonadotropin in Caski cells: A new epidermoid cervical cancer cell line, Science 196: 1456–1458.PubMedCrossRefGoogle Scholar
  61. Purola, E., and Savia, E., 1977, Cytology of gynecologic condyloma acuminatum, Acta Cytol. 21: 26–31.PubMedGoogle Scholar
  62. Rawls, W. E., Tompkins, W. A. F., Figueroa, M. E., and Melnick, J. L., 1968, Herpes simplex virus type 2: Association with carcinoma of the cervix, Science 161: 1255–1256.PubMedCrossRefGoogle Scholar
  63. Rawls, W. E., Clarke, A., Smith, K. O., Docherty, J. J., Gilman, S. C., and Graham, S., 1980, Specific antibodies to herpes simplex virus type 2 among women with cervical cancer, in: Viruses in Naturally Occurring Cancers ( M. Essex, G. Todaro, and H. zur Hausen, eds.), pp. 117–133, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  64. Rigoni-Stem, D., 1842, Fatti statistici relativi alle malatie cancerose, Giorn. Service Prog. Pathol. Terap. 2: 507–517.Google Scholar
  65. Rotkin, I. D., 1973, A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents, Cancer Res. 33: 1353–1367.PubMedGoogle Scholar
  66. Rüger, R., Bomkamm, G. W., and Fleckenstein, B., 1984, Human cytomegalovirus DNA sequences with homologies to the cellular genome, J. Gen. Virol. 65: 1351–1364.PubMedCrossRefGoogle Scholar
  67. Rutledge, F., and Sinclair, M., 1968, Treatment of intraepithelial carcinoma of the vulva by skin excision and graft, J. Obstet. Gynecol. 102: 806–818.Google Scholar
  68. Scheurlen, W., Stremlau, A., Gillmann, L., Höhn, D., Zenner, H.-P. and zur Hausen, H., 1986, Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma, Int. J. Cancer 38: 671–676.PubMedCrossRefGoogle Scholar
  69. Schlehofer, J. R., and zur Hausen, H., 1982, Induction of mutations within the host genome by partially inactivated herpes simplex virus type 1, Virology 122: 471–475.PubMedCrossRefGoogle Scholar
  70. Schlehofer, J. R., Gissmann, L., and zur Hausen, H., 1983, Herpes simplex virus induced amplification of SV40 sequences in transformed Chinese hamster embryo cells, Int. J. Cancer 32: 99–103.PubMedCrossRefGoogle Scholar
  71. Schneider, A., Kraus, H., Schuhmann, R., and Gissmann, L., 1985, Papillomavirus infection of the lower genital tract: Detection of viral DNA in gynecological swabs, Int. J. Cancer 35: 443–448.PubMedCrossRefGoogle Scholar
  72. Schwarz, E., Dürst, M., Demankowski, C., Lattermann, O., Zech, R., Wolfsperger, E., Suhai, S., and zur Hausen, H., 1983, DNA sequence and genome organization of genital human papillomavirus type 6b, EMBO J. 2: 2341–2348.PubMedGoogle Scholar
  73. Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., and zur Hausen, H., 1985, Structure and transcription of human papillomavirus sequences in cervical carcinoma cells, Nature 314: 111–114.PubMedCrossRefGoogle Scholar
  74. Seedorf, K., Krämmer, G., Dürst, M., Suhai, S., and Röwekamp, W. G., 1985, Human papillomavirus type 16 sequence, Virology 145: 181–186.PubMedCrossRefGoogle Scholar
  75. Shah, K. H., Lewis, M. G., Jenson, A. B., Kurman, R. J., and Lancaster, W. D., 1980, Papillomavirus and cervical dysplasia, Lancet 2: 1190.PubMedCrossRefGoogle Scholar
  76. Smith, P. G., Kinley, L. J., White, G. C., Adelstein, A. M., and Fox, A. J., 1980, Mortality of wives of men dying with cancer of the penis, Br. J. Cancer 41: 422–428.PubMedCrossRefGoogle Scholar
  77. Spalholz, B. A., Yang, Y.-C., and Howley, P. M., 1985, Trans-activation of a BPV-I enhancer, J. Cell Biochem. Suppl 9c: 89.Google Scholar
  78. Stremlau, A., Gissmann, L., Ikenberg, H., Stark, M., Bannasch, P., and zur Hausen, H., 1985, Human papillomavirus type 16-related DNA in an anaplastic carcinoma of the lung, Cancer 55: 737–740.CrossRefGoogle Scholar
  79. Syrjänen, K., de Villiers, E.-M., Saarikoski, S., Castren, O., Väyrynen, M., Mäntyjärvi, R., and Parkkinnen, S., 1985, Cervical papillomavirus infection progressing to invasive cancer in less than three years, Lancet 1: 510–511.PubMedCrossRefGoogle Scholar
  80. Teokharov, B. A., 1962, On the problem of the nature and epidemiology of acuminate condylomatosis, Vestn. Dermatol. Venerol. 36: 51–56.PubMedGoogle Scholar
  81. Vonka, V., Kanka, J., Jelinek, J., Subrt, I., Sucharek, A., Havrankova, A., Vachal, M., Hirsch, I., Domorazkova, E., Zavadova, H., Richterova, V., Naprstkova, J., Dvorakova, V., and Svoboda, B., 1984a, Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. I. Epidemiological characteristics, Int. J. Cancer 33: 49–60.PubMedCrossRefGoogle Scholar
  82. Vonka, V., Kanka, J., Hirsch, I., Zavadova, H., Krcmar, M., Suchankova, A., Rezakova, D., Broucek, J., Press, M., Domorazkova, E., Svoboda, B., Havrankova, A., and Jelinek, J., 1984b, Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. II. Herpes simplex type-2 antibody presence in sera taken at enrollment, Int. J. Cancer 33: 61–66.PubMedCrossRefGoogle Scholar
  83. Waterhouse, J., Muir, C., Shanmugaratnam, K., and Powell, J. (eds.), 1982, Cancer Incidence in Five Continents, Vol. 4, Int. Agric. Res. Cancer, Lyons.Google Scholar
  84. Wigle, D. T., 1980, Re: ‘Smoking and cancer of the cervix: Hypothesis,’ Am. J. Epidemiol. 111: 125–127.PubMedGoogle Scholar
  85. Winkelstein, W., Jr., 1977, Smoking and cancer of the uterine cervix, Am. J. Epidemiol. 106: 257–259.PubMedGoogle Scholar
  86. Yee, C., Krishnan-Hewlett, I., Baker, C. C., Schlegel, R., and Howley, P., 1985, Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines, Am. J. Pathol. 119: 361–366.PubMedGoogle Scholar
  87. zur Hausen, H., 1975, Oncogenic herpesvirus, Biochim. Biophys. Acta 417: 25–53.PubMedGoogle Scholar
  88. zur Hausen, H., 1976, Condylomata acuminata and human genital cancer, Cancer Res. 36: 794.PubMedGoogle Scholar
  89. zur Hausen, H., 1977, Human papillomaviruses and their possible role in squamous cell carcinomas, Curr. Top. Microbiol. Immunol. 78: 1–30.PubMedCrossRefGoogle Scholar
  90. zur Hausen, H., 1982, Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events? Lancet 2: 1370–1372.PubMedCrossRefGoogle Scholar
  91. zur Hausen, H., 1983, Herpes simplex virus in human genital cancer, Int. Rev. Exp. Pathol. 25: 307–326.PubMedGoogle Scholar
  92. zur Hausen, H., Meinhof, W., Scheiber, W., and Bornkamm, G. W., 1974, Attempts to detect virus-specific DNA in human tumors. I. Nucleic acid hybridizations with complementary RNA of human wart virus, Int. J. Cancer 13: 650–656.PubMedCrossRefGoogle Scholar
  93. zur Hausen, H., Gissmann, L., Steiner, W., Dippold, W., and Dregger, I., 1975, Human papilloma virus and cancer, Bibl. Haematol. (Basel) 43: 569–571.Google Scholar
  94. zur Hausen, H., Gissmann, L., and Schlehofer, J. R., 1984, Viruses in the etiology of human genital cancer, Prog. Med. Virol. 30: 170–186.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Harald zur Hausen
    • 1
  • Achim Schneider
    • 2
  1. 1.Deutsches KrebsforschungszentrumHeidelbergFederal Republic of Germany
  2. 2.Sektion für Gynäkologische Zytologie und HistologieUniversitäts-FrauenklinikUlmFederal Republic of Germany

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