Epidermodysplasia Verruciformis

  • Gérard Orth
Part of the The Viruses book series (VIRS)


Epidermodysplasia verruciformis (EV) is a rare lifelong skin disease, which begins during infancy or childhood. It is induced by numerous specific types of human papillomaviruses (HPVs), sometimes including the HPVs associated with flat warts in the general population. EV is characterized by refractory, disseminated skin lesions resembling flat warts, or presenting as macules of various colors. Cutaneous carcinomas in situ or invasive carcinomas usually of Bowen’s type, appear in a high proportion of the patients, generally at an early age. HPV DNA sequences, usually HPV type 5, are regularly detected in EV carcinomas. EV is a multifactorial disease which involves genetic, immunological, and extrinsic factors, in addition to specific HPVs. This has been suggested by the parental consanguinity and the sibling involvement observed in some cases, the impaired cell-mediated immunity reported in most patients, and the usual localization of skin cancers in light-exposed areas. Reviews on EV have been published by Maschkilleisson (1931), Sullivan and Ellis (1939), Midana (1949), Jablonska and Milewski (1957), Bilancia (1961), Jablonska et al. (1966, 1972), Oehlschlaegel et al. (1966), Relias et al. (1967), Tsoitis et al. (1973), Rueda and Rodriguez (1976), Kaufmann et al. (1978), Lutzner (1978), Orth et al. (1980), Jablonska and Orth (1985), and Orth (1986).


Skin Cancer Human Papilloma Virus Renal Allograft Recipient Epidermodysplasia Verruciformis Common Wart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Gérard Orth
    • 1
  1. 1.Unité des Papillomavirus, Unité INSERM 190Institut PasteurParis Cedex 15France

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