Organization and Expression of Papillomavirus Genomes
Although the papillomaviruses were discovered early in this century (Ciuffo, 1907; Shope, 1933), studies of their molecular properties progressed extremely slowly until the last decade. The lack of in vitro systems for virus cultivation has obviously been a retarding factor. Due to their morphological and physical properties, the papillomaviruses were assumed to be closely related to the other members of the papovavirus group, SV40 and polyomavirus (Melnick et al., 1974; Matthews, 1982). It was, however, recognized that both the papillomavirus particle (Strauss et al.,1950; Finch and Klug, 1965) and the viral chromosome (Crawford and Crawford, 1963; Favre et al.,1975; Gissmann and zur Hausen, 1976; Orth et al.,1977) were significantly larger than those of other papovaviruses.
KeywordsmRNA Species Splice Acceptor Site Epidermodysplasia Verruciformis Domestic Rabbit Bovine Papilloma Virus
Unable to display preview. Download preview PDF.
- Ahola, H., Bergman, P., Ström, A.-C., Moreno-Lopez, J., and Pettersson, U., 1986, Organization and expression of the transforming region of the European elk papillomavirus (EEPV), Gene 50 (in press).Google Scholar
- Chow, L. T., and Broker, T. R., 1984, Human papilloma virus type 1 RNA transcription and processing in COS-1 cells, in: Gene Transfer and Cancer ( M. L. Pearson and N. L. Steinberg, eds.) pp. 125–134, Raven Press, New York.Google Scholar
- Ciuffo, G., 1907, Innesto positivo con filtrado di verrucae volgare, G. Ital. Mal. Venereol. 48: 12–17.Google Scholar
- Danos, O., and Yaniv, M., 1983, Structure and function of papillomavirus genomes, in: DNA-virus Oncogenes and Their Action ( G. Klein, ed.), pp. 59–82, Raven Press, New York.Google Scholar
- Mellors, R. C., 1960, Tumor cell location of the antigens of the Shope papillomavirus and the Rous sarcomavirus, Cancer Res. 20: 744–746.Google Scholar
- Nassen, M., and Wettstein, F. O., 1984a, Differences exist between viral transcripts in cottontail rabbit papillomavirus induced benign and malignant tumors as well as non-virus producing and virus-producing tumors, J. Virol. 51: 706–712.Google Scholar
- Nassen, M., Wettstein, F. O., and Stevens, J. G., 1982, Two colinear and spliced viral transcripts are present in non-virus-producing benign and malignant neoplasms induced by the Shope (rabbit) papillomavirus, J. Virol. 44: 263–268.Google Scholar
- Pilacinski, W. P., Glassman, D. L., Krzyzek, R. A., Sadowski, P. L., and Robbins, A. K., 1984, Cloning and expression in Escherichia coli of the bovine papillomavirus Ll and L2 open reading frames, Biotechnology 1: 356–360.Google Scholar
- Sarver, N., Rabson, M. S., Yang, Y.-C., Byrne, J. C., and Howley, P. M., 1984, Localization and analysis of bovine papillomavirus type 1 transforming functions, J. Virol. S2: 377–388.Google Scholar
- Schwartz, E., Dürst, M., Demankowski, C., Lattermann, O., Zech, R., Wolfsperger, E., Suhai, S., and zur Hausen, H., 1983, DNA sequence and genome organization of genital human papillomavirus type 6b, EMBO J. 2: 2341–2348.Google Scholar
- Tooze, J., (ed.), 1981, DNA Tumour Viruses, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar